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Rabbit Anti-MARCH6/BF594 Conjugated antibody (bs-9340R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9340R-BF594
英文名稱 Rabbit Anti-MARCH6/BF594 Conjugated antibody
中文名稱 BF594標記的膜相關環指蛋白6抗體
別    名 Doa10 homolog; E3 ubiquitin protein ligase MARCH6; MARCH 6; MARCH VI; MARCHVI; Membrane associated RING CH protein VI; Membrane associated ring finger (C3HC4) 6; Membrane associated RING finger protein 6; Protein TEB 4; Protein TEB4; RNF 176; RNF176; TEB 4; TEB4; RING finger protein 176; MARH6_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞周期蛋白  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MARCH6
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.

Function:
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.

Subunit:
Interacts with DIO2.

Subcellular Location:
Endoplasmic reticulum membrane; Multi pass membrane protein.

Tissue Specificity:
Present in brain (at protein level).

Post-translational modifications:
Auto-ubiquitinated, which results in proteasomal degradation.

Similarity:
Contains 1 RING-CH-type zinc finger.

Database links:

Entrez Gene: 10299 Human

Entrez Gene: 223455 Mouse

Entrez Gene: 294862 Rat

Omim: 613297 Human

SwissProt: O60337 Human

SwissProt: Q6ZQ89 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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