超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號(hào)           掃碼咨詢(xún)技術(shù)支持           掃碼咨詢(xún)技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产日韩欧美在线播放,国产刚发育娇小性色xxxxx,熟女俱乐部五十路二区AV
Rabbit Anti-WNK4/PE-Cy3 Conjugated antibody (bs-0429R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢(xún)價(jià)
產(chǎn)品編號(hào) bs-0429R-PE-Cy3
英文名稱(chēng) Rabbit Anti-WNK4/PE-Cy3 Conjugated antibody
中文名稱(chēng) PE-Cy3標(biāo)記的WNK4抗體
別    名 PHA 2B; PHA2B; PRKWNK 4; PRKWNK4; Protein kinase lysine deficient 4; Protein kinase with no lysine 4; Serine/threonine protein kinase WNK4; WNK lysine deficient protein kinase 4; WNK4_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢(xún)價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  激酶和磷酸酶  通道蛋白  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 135kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human WNK4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L.

Subunit:
Interacts with the C-terminal region of KCNJ1 (By similarity). Interacts with WNK1 and WNK3 (By similarity).

Subcellular Location:
Cell junction, tight junction (By similarity). Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity).

Tissue Specificity:
Expressed in kidney, colon and skin.

Post-translational modifications:
Phosphorylated by WNK1 and WNK3.

DISEASE:
Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491]: An autosomal dominant disorder characterized by hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 65266 Human

Omim: 601844 Human

SwissProt: Q96J92 Human

Unigene: 105448 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

WNK4蛋白是一種新的絲氨酸/蘇氨酸激酶家族成員的基因,在遠(yuǎn)端腎小管表達(dá)(腎小管是腎臟的基本結(jié)構(gòu),在維持人體的水電解質(zhì)平衡方面有著重要的作用)而且,這一發(fā)現(xiàn)還有助于人們更好的了解腎臟的生理作用。
WNK4基因的發(fā)現(xiàn)是非常有意義的,WNK4的突變可能會(huì)引起高血壓病的發(fā)生,為人們研究血壓變化的發(fā)生機(jī)理提供了一個(gè)線索。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 99自拍| 亚洲高清国产拍精品影院 | 精品人妻无码一区二区三区换脸 | 在线欧美色| 欧美中文字幕一区二区三区亚洲 | 久久久亚洲精品无码 | 亚洲一区二区三区AV天堂 | 国产gv在线观看受被做哭 | 日韩不卡免费 | 精品国产高清自在线一区二区 | 把护士强奷到舒服的动态图 | 久久综合97丁香色香蕉 | 67194成人手机在线 | 色青青草原桃花久久综合 | 99久久人妻无码精品系列蜜桃 | 国产帅男男GAY网站视频 | 亚洲视频中文字幕在线 | 日韩精品一二三区 | 一级片韩国| 成人a∨欧美大片 | 久久9久久 | 久久国产精品99精国产 | chinese性内射高清5 | BAOYU最新无码网站在线观看 | 精品3atv在线视频 | 羞羞答答xxdd在线网站 | 特片网久久| 久久福利一区二区 | 国产网站91 | 一区二区三区四区免费视频 | 4438激情网| 国产亚洲精久久久久久无码77777 | 综合网中文字幕 | 国产在线精品一区二区中文 | 国产gv在线观看受被做哭 | 美女张开腿让男生桶视频 | 亚洲高清无码在线观看 | 噼里啪啦动漫在线观看免费 | 欧美精品videos另类 | 毛片毛片毛片毛片毛片 | 弄逼视频 |