超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲品质自拍视频,伊人久久大香线焦AV色,免费国产成人
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-WNK4/BF350 Conjugated antibody (bs-0429R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0429R-BF350
英文名稱 Rabbit Anti-WNK4/BF350 Conjugated antibody
中文名稱 BF350標記的WNK4抗體
別    名 PHA 2B; PHA2B; PRKWNK 4; PRKWNK4; Protein kinase lysine deficient 4; Protein kinase with no lysine 4; Serine/threonine protein kinase WNK4; WNK lysine deficient protein kinase 4; WNK4_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  激酶和磷酸酶  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 135kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human WNK4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

Function:
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L.

Subunit:
Interacts with the C-terminal region of KCNJ1 (By similarity). Interacts with WNK1 and WNK3 (By similarity).

Subcellular Location:
Cell junction, tight junction (By similarity). Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity).

Tissue Specificity:
Expressed in kidney, colon and skin.

Post-translational modifications:
Phosphorylated by WNK1 and WNK3.

DISEASE:
Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491]: An autosomal dominant disorder characterized by hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 65266 Human

Omim: 601844 Human

SwissProt: Q96J92 Human

Unigene: 105448 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

WNK4蛋白是一種新的絲氨酸/蘇氨酸激酶家族成員的基因,在遠端腎小管表達(腎小管是腎臟的基本結(jié)構(gòu),在維持人體的水電解質(zhì)平衡方面有著重要的作用)而且,這一發(fā)現(xiàn)還有助于人們更好的了解腎臟的生理作用。
WNK4基因的發(fā)現(xiàn)是非常有意義的,WNK4的突變可能會引起高血壓病的發(fā)生,為人們研究血壓變化的發(fā)生機理提供了一個線索。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 成人a在线视频免费观看 | 18禁无遮挡啪啪无码网站 | 啊灬啊灬啊灬快灬高潮少妇 | 亚洲AV无码午夜国产精品色软件 | 亚洲高清国产拍精品影院 | 久久综合色视频 | 超碰在线94| 欧美国产片 | 五月网址 | 日本一区精品视频 | 超鹏97国语 | 欧美一级一级一级 | 日本一区二区三区视频免费看 | 久久精品国产99国产精品亚洲 | 欧美日韩亚洲视频 | 天天综合色天天综合色h | 亚洲欧美久久久 | 91九色最新地址 | 中文字幕第三区 | 久久成年片色大黄全免费网站 | 久久国产精品嫩草影院的推荐理由 | 亚洲精品欧美综合二区 | 久久精品国产亚洲blacked | 第一次破處在线国语视频播放 | 中文字幕日本在线 | 永夜星河短剧免费观看 | 日日久视频 | haodiaocao的视频这里看 | 黄色大片毛片 | 中文字幕AV伊人AV无码AV狼人 | 老司机在线观看福利网站视频 | 亚洲a黄| 特级黄一级播放 | 丰满少妇被猛烈进入毛片 | 欧美另类极品 | 国产在线一区二区三区激情欧美 | 丝袜国偷自产中文字幕亚洲第一页 | 午夜a级理论片在线播放琪琪 | 蜜桃视频精品区 | 男人女人一边躁一边爽 | 亚洲国产成人精品无码区二本 |