超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲精品无码成人片久久不卡,久久精品色,青草视频免费在线观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-E2F1 (Ser364)/PE-Cy7 Conjugated antibody (bs-4076R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4076R-PE-Cy7
英文名稱 Rabbit Anti-phospho-E2F1 (Ser364)/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的磷酸化轉錄因子E2F-1抗體
別    名 E2F1 (phospho S364); E2F1 (phospho Ser364); p-E2F1 (S364); p-E2F1 (Ser364); E2F 1; E2F transcription factor 1; E2F-1; E2f1 E2F transcription factor 1; KIAA4009; mKIAA4009; OTTHUMP00000030661; PBR 3; PBR3; PRB binding protein E2F 1; PRB-binding protein E2F-1; RBAP 1; RBAP-1; RBAP1; RBBP 3; RBBP-3; RBBP3; RBP 3; RBP3; Retinoblastoma associated protein 1; Retinoblastoma binding protein 3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3; Transcription factor E2F1; E2F1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, )
產品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human E2F1 around the phosphorylation site of Ser364
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.

Subunit:
Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Interacts with TRRAP, which probably mediates its interaction with histone acetyltransferase complexes, leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. Interacts with TRIM28; the interaction inhibits E2F1 acetylation through recruiting HDAC1 and represses its transcriptional activity. Interaction with KAT2B; the interaction acetylates E2F1 enhancing its DNA-binding and transcriptional activity. Interacts with BIRC2/c-IAP1 (via BIR domains). Interacts with human cytomegalovirus/HHV-5 protein UL123.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.

Similarity:
Belongs to the E2F/DP family.

Database links:

Entrez Gene: 1869 Human

Entrez Gene: 13555 Mouse

Entrez Gene: 399489 Rat

Omim: 189971 Human

SwissProt: Q01094 Human

SwissProt: Q61501 Mouse

SwissProt: O09139 Rat

Unigene: 654393 Human

Unigene: 18036 Mouse

Unigene: 72471 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

E2F1—屬于調節性轉錄因子E2F家族。有學者認為:E2F-1既可作為癌基因起作用,又可作為抑癌基因起作用。其不同可能由細胞中其他生長促進或抑制性蛋白質水平和(或)活性決定,同時與細胞所處環境及器官特異性有關。在控制細胞周期和腫瘤抑制基因蛋白的活性方面起關鍵作用。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产在线高清视频无码不卡互動交流 | 边摸边脱吃奶边高潮视频免费 | 五月天婷婷导航 | 欧美日韩黄视频 | 大地资源网高清在线观看视频 | 免费成人91 | 久夜蜜汁av玖潮碰撩尤物 | 中文字幕视频在线看 | 黄网十三区| 羞羞答答成人影院www | 国产成人综合在线女婷五月99播放 | 中文字幕色视频 | 亚洲色成人一区二区三区小说 | 久久香蕉网站 | 啦啦啦资源在线观看视频 | 欧美日韩一区二区三区精品 | 天天综合网久久 | 免费aaa级毛片在线视频 | 猛草视频 | 亚洲精品一区二区三区不 | 午夜裸体女人视频网站在线观看 | 免费av中文字幕 | 午夜天堂成人欧美www无码 | 99热国产在线手机精品 | 不卡视频一区 | caoporn最新地址 | 人妻无码不卡中文字幕在线视频 | 国产亚洲综合专区在线在线观看 | 人妻无码中文字幕一区二区三区 | 一本大道香蕉在线视频 | 国产精品香蕉 | 午夜精品久久久久久久99老熟妇 | 91美女吸乳羞羞网站 | 无码内射成人免费喷射 | 久久午夜精品影院一区 | 免费观看欧美日韩亚洲 | 91大神一区二区三区在线观看 | 狼亚洲AV无码专区在线播放中文 | 欧美日韩久久久精品A片妖精 | 欧美精品久久久久久久久久丰满 | 91视频污版 |