超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产性xxxx18免费观看视频,一级毛片一级毛片一级毛片aa一,亚洲欧洲自拍偷拍
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-LATS2/RBITC Conjugated antibody (bs-4081R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4081R-RBITC
英文名稱 Rabbit Anti-LATS2/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的腫瘤抑制基因LATS2抗體
別    名 Kinase phosphorylated during mitosis; KPM; Large tumor suppressor homolog 2; Large tumor suppressor homolog 2 Drosophila; LATS large tumor suppressor Drosophila homolog 2; LATS large tumor suppressor homolog 2; Serine/threonine kinase kpm; Serine/threonine protein kinase kpm; Warts like kinase; FLJ13161; Kinase phosphorylated during mitosis protein; Large tumor suppressor kinase 2; Lats2; LATS2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LATS2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq].

Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.

Subunit:
Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole.

Tissue Specificity:
Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.

Post-translational modifications:
Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3/MST2.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 UBA domain.

Database links:

Entrez Gene: 26524 Human

Entrez Gene: 50523 Mouse

Entrez Gene: 305922 Rat

Omim: 604861 Human

SwissProt: Q9NRM7 Human

SwissProt: Q7TSJ6 Mouse

Unigene: 78960 Human

Unigene: 347899 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产亚洲精品久久777777 | 中日韩在线观看 | 女人与动zzz0000xxxx | 成人va在线| 五十路熟女の豊満な肉体 | 中国xxxxhd | 国色天香卡一卡二乱码 | 人妻系列无码中文字幕专区 | 日本免费无遮挡吸乳视频网站 | 人和牛交VIDE欧美 | 特级黄毛片 | 日本特黄特色大片免费视频老年人 | 亚洲热视频在线观看 | 91xxx在线观看 | 欧美日韩一卡2卡三卡4卡乱码欧美孕交 | 国产成人在线播放免费视频 | SM调教室论坛首页入口 | 91精品久久久久五月天精品 | 青青热久免费精品视频在线播放 | 国产午夜福利片 | 亚洲国产精品免费在线观看 | 久久久久美女 | 成A人影片免费观看日本 | 国产69精品久久久久99 | 女人一级一片30分 | 日韩人妻无码精品系列专区 | 国产中文字幕在线免费观看 | 国产女人被狂躁到高潮小说 | 精品久久久久久久久久久久久久久久久久久 | 打工女人内毛片 | av狼最新网址 | 97成人资源站 | 秋霞鲁丝片一区二区三区 | 亚洲国产精品久久久久久 | 免费网站在线观看黄 | 一区在线视频观看 | 一色桃子视频 | 国产成人XXXXX免费视频 | av毛片在线观看地址 | 狠狠躁18三区二区一区 | 久久99精品国产自在现线小黄鸭 |