超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
骚虎av在线网站,丝袜美女视频性感美女,嫩草影院免费观看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-RAD9/Gold Conjugated antibody (bs-4179R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-4179R-Gold
英文名稱 Rabbit Anti-RAD9/Gold Conjugated antibody
中文名稱 膠體金標記的細胞周期檢查控制蛋白質抗體
別    名 Cell cycle checkpoint control protein; Cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD 9; hRAD9; Rad 9; RAD 9A; RAD9 (S pombe) homolog; RAD9 homolog A; RAD9 homolog; RAD9A; RAD9A_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  染色質和核信號  信號轉導  細胞凋亡  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RAD9 (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq].

Function:
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Subunit:
Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2. Interacts with DNAJC7 and RHNO1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex.

Similarity:
Belongs to the rad9 family.

Database links:

Entrez Gene: 5883 Human

Entrez Gene: 19367 Mouse

Entrez Gene: 100361529 Rat

Omim: 603761 Human

SwissProt: Q99638 Human

SwissProt: Q9Z0F6 Mouse

Unigene: 655354 Human

Unigene: 277629 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Rad9有391個AA構成,Rad9有很多重要生物學功能,如:可調控DNA損傷反應、調節細胞的周期、對損傷的DNA進行修復、誘導細胞凋亡、調控部分基因的轉錄、具有3’端到5’端核酸外切酵素(exonuclease)的活性、促進核糖核酸的生合成以及參與胚胎發育過程。 曾有報道指出Rad9在調節細胞周期、誘導細胞凋亡及維持整個基因體的完整性等方面的生物功能都和p53極為相似,因此Rad9及p53這兩種蛋白在功能上可能具有相互協調作用。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲日韩看片无码超清 | 2018av天堂在线视频精品观看 | www.youjizz.com最新 | 天天想夜夜操 | 成人免费777777被爆出 | 亚洲国产97色在线张津瑜 | 弄逼视频| 亚洲午夜精品A片一区二区三区 | 久久影院久久 | 人摸人人人澡人人超碰 | 五月婷婷中文字幕 | 无码人妻视频一区二区三区 | 4438╳全国最大色倩网址 | 超碰caoporm97| www.亚洲视频.com | FREEZEFRAME丰满老妇 | 国产精品88久久久久久妇女 | 久久av每日更新免费观看 | 久章草在线精品视频免费观看 | 女人高潮视频网站 | 在线黄色免费 | 精品少妇一区二区三区在线视频 | 邻居少妇张开腿让我爽了一夜 | 国产亚洲一区二区视频 | 日韩中出 | 国产99久久久国产精品免费看 | 欧美人成在线视频 | 屁股大丰满高潮尖叫视频 | av鲁丝一区鲁丝二区鲁丝三区 | 久久午夜无码鲁丝片 | 夜色资源ye321在线观看 | 91高清免费视频 | 国产视频二区在线观看 | 欧美成人v | 手机看片被窝午夜婷婷国产 | 狠狠色婷婷久久一区二区三区 | 特级毛片免费看 | 超碰caoporm97| 国产日日日 | 成人在线视 | 欧美一级播放 |