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Rabbit Anti-kappa Opioid receptor/RBITC Conjugated antibody (bs-1094R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1094R-RBITC
英文名稱 Rabbit Anti-kappa Opioid receptor/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的kappa型阿片受體抗體
別    名 Kappa type opioid receptor; KOR 1; KOR; Opiate receptor kappa 1; OPRK 1; OPRK; OPRK1; Oprk2; R21; OPRK_HUMAN.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  神經生物學  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, 
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human kappa Opioid receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain, consciousness, motor control, mood, and autonomic function, and can induce physical dependence. Pharmacological studies suggested that there are at least 3 major classes of opioid receptors, designated delta, kappa, and mu. They differ in their affinity for various opioid ligands and in their cellular distribution. Studies of the receptors in the mouse and rat show that they are structurally related and are members of the family of 7 transmembrane-spanning G protein-coupled receptors. The kappa opiod receptor inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. It is the receptor for beta-endorphin.

Function:
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Subunit:
Interacts with SLC9A3R1. Interacts with GABARAPL1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 4986 Human

Omim: 165196 Human

SwissProt: P41145 Human

Unigene: 106795 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

kappa型阿片受體在人腦和胎盤組織中有分布。κ- 受體參與鎮痛 ,且與神經內分泌及免疫調節有關。此外,κ受體也調控噴他佐辛樣脊髓鎮痛、鎮靜和瞳孔縮小。κ-阿片受體由380個氨基酸組成,同樣屬于G蛋白偶聯受體家族。
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