超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
色偷偷9999WWW,国产免费精彩视频,四川xxxxxlmedjyf本电
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-SIRT6 (Ser338)/BF555 Conjugated antibody (bs-5634R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5634R-BF555
英文名稱 Rabbit Anti-phospho-SIRT6 (Ser338)/BF555 Conjugated antibody
中文名稱 BF555標記的磷酸化沉默調(diào)節(jié)相關(guān)蛋白6抗體
別    名 SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  細胞凋亡  新陳代謝  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.

Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Subunit:
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.

Subcellular Location:
Nucleus, nucleoplasm.

Similarity:
Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.

Database links:

Entrez Gene: 51548 Human

Entrez Gene: 50721 Mouse

Entrez Gene: 299638 Rat

Omim: 606211 Human

SwissProt: Q8N6T7 Human

SwissProt: P59941 Mouse

Unigene: 423756 Human

Unigene: 131825 Mouse

Unigene: 25643 Mouse

Unigene: 8108 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SIRT6是一種酶,能夠從組蛋白的一個特定位點上移走稱之為乙酰基組的化學(xué)物質(zhì)。組蛋白對調(diào)控基因表達非常重要,而從組蛋白中移除乙酰基組就會“關(guān)閉”某些基因表達。 SIRT6蛋白與NF-kappaB(NF-kB)一同,可以調(diào)節(jié)凋亡、炎癥和新陳代謝相關(guān)基因的作用。當減少SIRT6時,NF-kappaB變得過度活躍,開啟同衰老相關(guān)的基因。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 超碰婷婷 | 日韩免费看 | 美女黄的视频全免费 | 日韩欧美国产一区二区三区 | 亚洲日韩中文字幕在线播放 | 成人免费a级片 | av狼友永久免费网址观看 | 日韩中文字幕一区二区高清99 | 亚洲AV无码乱码在线观看看 | 精品一区二区av | 久久国产自偷自偷免费一区调 | 亚洲成A人片在线观看中文无码 | 亚洲三级在线看 | 欧美成人免费在线 | 亚洲精品无码AV专区最新 | 99精品国产高清一区二区麻豆 | 久操免费在线视频 | 欧美XXXX做受欧美69 | 欧产日产国产精品98 | 精品国产免费人成网站 | 久久人人爽爽爽人久久久 | 超碰伊人av | 91精品国产一区二区三区在线 | 亚洲男女内射在线播放 | 欧美黄视频在线观看 | 91蜜桃臀久久一区二区 | 国产日韩精品在线免费播放 | 无码人妻视频一区二区三区 | 筋肉雄汁gay雄汁外送网站 | 美女视频黄a视频全免费网站一区 | 一区二区高清 | 国产精品人妻无码久久久苍井空 | 日韩人妻无码精品系列专区 | 在线中文字幕网 | 亚洲巨乳自拍在线视频 | 99热久RE这里只有精品小草 | av大片在线免费观看 | 久久久久国产精品熟女影院浪 | 成人黄色a视频 | 国产户外野战AV一级 | 色综合视频一区二区三区高清 |