超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
色偷偷9999WWW,国产免费精彩视频,四川xxxxxlmedjyf本电
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-SIRT6 (Ser338)/BF555 Conjugated antibody (bs-5634R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5634R-BF555
英文名稱 Rabbit Anti-phospho-SIRT6 (Ser338)/BF555 Conjugated antibody
中文名稱 BF555標記的磷酸化沉默調(diào)節(jié)相關(guān)蛋白6抗體
別    名 SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  心血管  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  細胞凋亡  新陳代謝  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.

Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Subunit:
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.

Subcellular Location:
Nucleus, nucleoplasm.

Similarity:
Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.

Database links:

Entrez Gene: 51548 Human

Entrez Gene: 50721 Mouse

Entrez Gene: 299638 Rat

Omim: 606211 Human

SwissProt: Q8N6T7 Human

SwissProt: P59941 Mouse

Unigene: 423756 Human

Unigene: 131825 Mouse

Unigene: 25643 Mouse

Unigene: 8108 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SIRT6是一種酶,能夠從組蛋白的一個特定位點上移走稱之為乙酰基組的化學(xué)物質(zhì)。組蛋白對調(diào)控基因表達非常重要,而從組蛋白中移除乙酰基組就會“關(guān)閉”某些基因表達。 SIRT6蛋白與NF-kappaB(NF-kB)一同,可以調(diào)節(jié)凋亡、炎癥和新陳代謝相關(guān)基因的作用。當減少SIRT6時,NF-kappaB變得過度活躍,開啟同衰老相關(guān)的基因。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 免费观看一级欧美片 | 一级毛片一级黄片 | 久久99色 | 九九热精品在线播放 | 好硬好湿好爽再深一点动态图片 | www.久久网站| japanese色系home中文 | 太大太粗太爽免费视频 | 国产一区二区三区四区五区tv | 一本一道人人妻人人妻αv 美女全黄视频 | 人妻无码AV天堂二区网站 | 亚洲中文久久精品无码浏不卡 | 成人毛片100免费观看 | 天天影视色香欲综合久久 | 上司部长出轨漂亮人妻 | 日本四虎影院 | 99er在线观看视频 | 色偷偷成人网免费视频男人的天堂 | 中文字幕在线播放不卡 | 国产精欧美一区二区三区久久 | 久久国产福利国产秒拍 | 日日操夜夜爱 | 亚洲色欧美在线影院 | 久久人操 | 99在线精品免费视频九九视 | 欧美成人第一页 | av免费在线视 | 国产精品久久久久精女同 | 精品久久久久久久久久国产潘金莲 | 国产精品国产三级国产在线观什 | 袖珍幻女bbwxxxx | 夜夜躁狠狠躁日日躁202 | 欧美最猛黑人xxxx黑人猛叫黄 | 在线一级片 | 国产一区毛片 | 亚洲精品人成网在线播放影院 | 日韩国产欧美精品一区二区三区 | 中文字幕无码精品亚洲资源网久久 | 欧美亚一区二区 | 欧美中文字幕 | 欧美人与动人物姣配XXXX |