超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美日韩色综合,久久精品30,91琪琪在线
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-SIRT6 (Ser338)/PE-Cy5.5 Conjugated antibody (bs-5634R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5634R-PE-Cy5.5
英文名稱 Rabbit Anti-phospho-SIRT6 (Ser338)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的磷酸化沉默調節相關蛋白6抗體
別    名 SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  免疫學  染色質和核信號  信號轉導  細胞凋亡  新陳代謝  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.

Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Subunit:
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.

Subcellular Location:
Nucleus, nucleoplasm.

Similarity:
Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.

Database links:

Entrez Gene: 51548 Human

Entrez Gene: 50721 Mouse

Entrez Gene: 299638 Rat

Omim: 606211 Human

SwissProt: Q8N6T7 Human

SwissProt: P59941 Mouse

Unigene: 423756 Human

Unigene: 131825 Mouse

Unigene: 25643 Mouse

Unigene: 8108 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SIRT6是一種酶,能夠從組蛋白的一個特定位點上移走稱之為乙酰基組的化學物質。組蛋白對調控基因表達非常重要,而從組蛋白中移除乙酰基組就會“關閉”某些基因表達。 SIRT6蛋白與NF-kappaB(NF-kB)一同,可以調節凋亡、炎癥和新陳代謝相關基因的作用。當減少SIRT6時,NF-kappaB變得過度活躍,開啟同衰老相關的基因。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲狠狠做深爱婷婷影院 | www.久久草.com | 久草在线视频免赞 | 91精品亚洲影视在线观看 | 最新zooskoovideos欧美异 | 久久久er热这里只有精品2 | 久久AV高潮AV无码AV喷吹 | 亚洲国产欧美一区二区三区久久 | 国产精品久久久久久福利 | 69免费观看| 国产自产精品一区 | 国产一级毛片不卡视频 | 新婚少妇无套内谢国语播放 | 国产精品无码日韩欧 | 91中文视频 | 91久久精品综合 | 亚洲av无码一区二区大桥未久 | 日韩精品久久久毛片一区二区 | 91老司机福利在线 | 亚洲欧美日本国产综合 | 91sex国产在线观看 | 国产成人综合精品无码 | WWW亚洲色大成网络.COM | 青青小草AV一区二区三区 | 91久久极品少妇xxxxⅹ软件 | 欧美美乳视频网站在线观看 | 国产成人无码精品久久灭火器 | 国产AV无码专区亚洲AV桃花庵 | 亚洲一区日本 | 人人澡人人澡人人看添AV | 久久精品视频18 | av免费看国产 | 五十路六十路老熟妇a片 | 无码国产精品亚洲а∨天堂dvd | 顶臀精品视频www | 浓精喷进老师黑色丝袜 | 大学生寝室白袜自慰gay网站 | 国产甜淫av片免费观看 | 精品国产第一区二区三区 | 午夜免费福利片 | 男人J放进女人P全黄在线 |