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Rabbit Anti-Leptin/Biotin Conjugated antibody (bs-4604R-Bio)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-4604R-Bio
英文名稱 Rabbit Anti-Leptin/Biotin Conjugated antibody
中文名稱 生物素標記的瘦素抗體
別    名 LEP; Leptin Murine Obesity Homolog; Leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog Leptin; OBS.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  生長因子和激素  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Leptin.
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Leptin, the product of the ob (obese) gene, is a 16kD protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. It targets the central nervous system, particularly hypothalamus, affecting food intake. Leptin levels are high in most obese individuals. Studies have shown that it may also influence reproductive function.

Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

Subunit:
Interacts with SIGLEC6.

Subcellular Location:
Secreted.

DISEASE:
Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the leptin family.

Database links:

Entrez Gene: 3952 Human

Entrez Gene: 16846 Mouse

Entrez Gene: 25608 Rat

Omim: 164160 Human

SwissProt: P41159 Human

SwissProt: P41160 Mouse

SwissProt: P50596 Rat

Unigene: 194236 Human

Unigene: 277072 Mouse

Unigene: 44444 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Leptin是一種分子量為16kDa的脂肪組織源激素,又稱:肥胖蛋白(Obese-protein)是由脂肪細胞分泌的,具有強親水性,以單體形式存在于血漿中。 Leptin 具有廣泛的生物學效應,作用于下丘腦,調節食欲、能量代謝及體重。Leptin 還可能作為脂肪-胰島內分泌軸的一部分,參與胰島素分泌的調節。
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