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Rabbit Anti-PHLP/Biotin Conjugated antibody (bs-5812R-Bio)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5812R-Bio
英文名稱 Rabbit Anti-PHLP/Biotin Conjugated antibody
中文名稱 生物素標記的腫瘤抑制基因PHLPP抗體
別    名 hSCOP; PH domain and leucine rich repeat protein phosphatase; PH domain leucine rich repeat containing protein phosphatase; PH domain leucine rich repeat protein phosphatase; PH domain leucine-rich repeat protein phosphatase; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase; PH domain-containing family E member 1; PHLP1_HUMAN; PHLPP1; Pleckstrin homology domain containing family E protein 1; Pleckstrin homology domain-containing family E member 1; Pleckstrin homology domain-containing family E protein 1; PLEKHE 1 protein; SCN circadian oscillatory protein; SCOP; SUPRACHIASMATIC NUCLEUS CIRCADIAN OSCILLATORY PROTEIN; Suprachiasmatic nucleus circadian protein.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞凋亡  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Chicken, Pig, Horse, Rabbit, )
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PHLP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

Subunit:
Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.

Similarity:
Belongs to the phosducin family.

Database links:

Entrez Gene: 5082 Human

Entrez Gene: 67466 Mouse

Entrez Gene: 64013 Rat

Omim: 604421 Human

SwissProt: Q13371 Human

SwissProt: Q9DBX2 Mouse

SwissProt: Q63737 Rat

Unigene: 271749 Human

Unigene: 620774 Human

Unigene: 30709 Mouse

Unigene: 51153 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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