超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
午夜一区二区视频,日韩一区二区三区免费,国产骚熟
Rabbit Anti-NG2/BF647 Conjugated antibody (bs-5829R-BF647)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-5829R-BF647
英文名稱 Rabbit Anti-NG2/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的黑色素瘤硫酸軟骨素蛋白多糖抗體
別    名 MELCSPG; AN2; AN2 proteoglycan; Chondroitin sulfate proteoglycan 4 (melanoma-associated); Chondroitin sulfate proteoglycan 4; CSPG4; Cspg4 chondroitin sulfate proteoglycan 4; HMW-MAA; HSN tumor-specific antigen; MCSP; MCSPG; MEL-CSPG; Melanoma chondroitin sulfate proteoglycan; Melanoma-associated chondroitin sulfate proteoglycan; MSK16; CSPG4_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  細(xì)胞粘附分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G)
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 248kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MCSPG
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Proteoglycans (PGs) are a family of proteins composed of different polypeptide chains containing glycosaminoglycan (GAG) modifications. They vary in their cellular locations and have diverse structure and functions. NG2 is a proteoglycan found in the nervous system, comprising a large integral membrane PG with a core protein of 300 kDa and at least one covalently attached chondroitin sulfate (CS) GAG chain. In the CNS this protein is expressed mainly on the surfaces of developing and adult oligodendrocyte precursor cells, but is also associated with developing chondrocytes, cardiomyocytes, pericytes and several human tumours. NG2 also stimulates alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Function:
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Subunit:
Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.

Subcellular Location:
Apical cell membrane. Cell projection > lamellipodium membrane. Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes.

Tissue Specificity:
Detected only in malignant melanoma cells.

Post-translational modifications:
O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility (By similarity).

Similarity:
Contains 15 CSPG (NG2) repeats.
Contains 2 laminin G-like domains.

Database links:

Entrez Gene: 1464 Human

Entrez Gene: 121021 Mouse

Omim: 601172 Human

SwissProt: Q6UVK1 Human

SwissProt: Q8VHY0 Mouse

Unigene: 513044 Human

Unigene: 41329 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 亚洲精品乱码久久久久久蜜桃91 | 国产精品久久久久久久久婷婷 | 国产精品美女久久久m | 成人xxxx视频| 中国av免费在线观看 | 日韩欧美高清DVD碟片 | 亚洲毛片一区二区 | 免费又色又爽又黄的舒服软件 | 草逼网首页 | 欧美激情自拍偷拍 | 222亚洲伊人成无码综合网 | 欧美人与禽ZOZ0善交 | 粗大黑人巨精大战欧美成人 | 翁公粗大挺进王丽霞高潮嗨文 | 国产精品无码一区二区三区免费 | 精品二区在线 | 亚洲自偷自拍熟女另类 | 亚洲成国产人片在线观看 | 国产v片在线免费观看 | 国产精品一区二区三区四 | 久草成人在线观看 | 热国产热综合 | 91久久精品一区 | chinese中国人妻4p对白视频 | 久久亚洲av无码精品色午夜麻 | 欧美人牲口杂交在线播放免费 | 国产成人无码免费视频79 | 亚洲精品一区二区不卡 | 亚洲美女在线播放 | 日韩高清不卡无码av | 一级国产精品一级国产精品片 | 亚洲欧洲日产国码高潮 | 久草av一区 | 国产女女做受ⅹxx高潮 | 久久17 | 欧美毛茸茸 | 久久影院一区二区 | 欧美日韩人妻精品一区二区在线 | 国产一区二区片 | 在线亚洲一区二区 | 五十路熟女の豊満な肉体 |