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Rabbit Anti-CTHRC1/BF555 Conjugated antibody (bs-5882R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5882R-BF555
英文名稱 Rabbit Anti-CTHRC1/BF555 Conjugated antibody
中文名稱 BF555標記的膠原三股螺旋重復蛋白1抗體
別    名 Collagen triple helix repeat containing 1; Collagen triple helix repeat containing protein 1; Collagen triple helix repeat-containing protein 1; CTHR1_HUMAN; Cthrc1; NMTC1 protein; Protein NMTC1.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  免疫學  信號轉導  生長因子和激素  細胞骨架  細胞外基質  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CTHRC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
CTHRC1 is a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.

Function:
May act as a negative regulator of collagen matrix deposition (By similarity).

Subcellular Location:
Secreted, extracellular space, extracellular matrix (By similarity).

Tissue Specificity:
Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.

Post-translational modifications:
N-glycosylated (By similarity).

DISEASE:
Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Contains 1 collagen-like domain.

Database links:
UniProtKB/Swiss-Prot: Q96CG8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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