| 產(chǎn)品編號 | bs-11836R-Gold |
| 英文名稱 | Rabbit Anti-Dact2/Gold Conjugated antibody |
| 中文名稱 | 膠體金標(biāo)記的Dapper2蛋白抗體 |
| 別 名 | bA503C24.7; C6orf116; Chromosome 6 open reading frame 116; Dact2; DACT2_HUMAN; Dapper antagonist of beta catenin homolog 2; Dapper antagonist of beta catenin homolog 2 Xenopus laevis; Dapper homolog 2 antagonist of beta catenin; Dapper homolog 2 antagonist of beta catenin xenopus; Dapper homolog 2; DAPPER2; DPR2; FLJ31232; MGC133141; MGC133142 ; RP11 503C24.7. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 83kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Dact2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: Dapper2 is a 774 amino acid protein that exists as multiple alternatively spliced isoforms and is a mammalian homolog of the Xenopus laevis protein dapper. Containing a C-terminal PDZ-binding motif, Dapper2 is thought to promote the lysosomal degradation of nodal receptors, possibly functioning to negatively regulate the nodal signaling pathway. The gene encoding Dapper2 maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. Function: Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. Subunit: Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity). Similarity: Belongs to the dapper family. Database links: UniProtKB/Swiss-Prot: Q5SW24.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
