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Rabbit Anti-SLC6A7/APC Conjugated antibody (bs-12124R-APC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12124R-APC
英文名稱 Rabbit Anti-SLC6A7/APC Conjugated antibody
中文名稱 APC標記的鈉依賴性脯氨酸轉運PROT抗體
別    名 SC6A7_HUMAN; Slc6a7; Sodium-dependent proline transporter; Solute carrier family 6 member 7; PROT.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  通道蛋白  細胞膜受體  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC6A7/PROT
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The GAT1 gene family includes sodium- and chloride-dependent plasma membrane transporters for neurotransmitters, metabolites and osmolites, which couple substrate flux to transmembrane electrochemical gradients. PROT (Sodium-dependent proline transporter), also known as Solute carrier family 6 member 7, is a 636 amino acid multi-pass membrane protein that is a GAT1 family member specifically expressed in regions of the brain. PROT terminates the action of proline by its high affinity sodium/chloride-dependent reuptake into pre-synaptic terminals. Enriched in glutamatergic synaptic terminals, it is likely that PROT plays an important role in excitatory events of neurotransmission. PROT-mediated proline uptake is inhibited by compounds such as benztropine, LP-403812 and Des-Tyr-Leu-enkephalin (GGFL). These inhibitors of proline uptake may lead to the development of therapeutic agents for certain neurologic disorders.

Function:
Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals.

Subcellular Location:
Membrane.

Tissue Specificity:
Brain.

Similarity:
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
SLC6A7 subfamily.

Database links:

Entrez Gene: 6534 Human

Entrez Gene: 117100 Rat

Omim: 606205 Human

SwissProt: Q99884 Human

SwissProt: P28573 Rat

Unigene: 241597 Human

Unigene: 9663 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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