超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
夜夜躁狠狠躁,久久综合区,日韩免费无码成人久久久久久片
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SPG3A/RBITC Conjugated antibody (bs-11759R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11759R-RBITC
英文名稱 Rabbit Anti-SPG3A/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的G蛋白結合蛋白3抗體
別    名 Atlastin; AD FSP; atl1; ATLA1_HUMAN; Atlastin GTPase 1; Atlastin-1; Atlastin1; Brain specific GTP binding protein; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Guanylate binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG 3A; SPG3; SPG3A.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  結合蛋白  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPG3A/Atlastin (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.

Function:
GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.

Subunit:
Homooligomer. Interacts (via N-terminal region) withMAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 andRTN4 (via the transmembrane region). Interacts with SPAST;interaction is direct. May interact with TMED2. Interacts withREEP1.

Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell projection > axon.

Tissue Specificity:
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).

DISEASE:
Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3) [MIM:182600]; also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Similarity:
Belongs to the GBP family. Atlastin subfamily.

Database links:

Entrez Gene: 51062 Human

Entrez Gene: 73991 Mouse

Entrez Gene: 362750 Rat

Entrez Gene: 535424 Cow

Omim: 606439 Human

SwissProt: Q58D72 Cow

SwissProt: Q8WXF7 Human

SwissProt: Q8BH66 Mouse

SwissProt: Q6PST4 Rat

Unigene: 584905 Human

Unigene: 474462 Mouse

Unigene: 135117 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 在线观看日本高清二区 | 国产精品青草久久 | 天堂va欧美ⅴa亚洲va | av无码理论片在线观看免费网站 | 日日爽天天干 | 男人的天堂Aⅴ在线无码 | 亚洲精品一区二区不卡 | 超碰99久久 | 97人妻免费碰视频碰免 | 欧美无毛视频 | 五月婷久 | 人与动人物XXXX毛片人与狍 | 一级片久久久久久 | 亚洲成人黄色网址 | 插插天天| 亚洲人和日本人hd | 五月婷激情| 无码人妻精品专区在线视频 | 国产伦精品一区二区三区视频金莲 | 99无码人妻一区二区三区免费 | 国产精品久久久久久亚洲色 | 啪啪黄色片 | 中文字幕色婷婷在线视频 | 久久午夜夜伦鲁鲁一区二区 | bb日韩美女预防毛片视频 | 影音先锋男人AV鲁色资源网 | 91精品国产麻豆 | 免费网站在线观看黄 | 亚洲高清国产拍精品动图 | 九色porny蝌蚪视频 | 四川骚妇无套内射舔了更爽 | 久久久久福利视频 | 青青青青久在线视频免费观看 | 全球av在线 | 久草com | 国产高清视频一区二区在线观看 | 国产精品视频免费一区二区 | 国产91影院 | 国产中文字幕亚洲 | av大片在线免费观看 | 国产乱码久久久久久 |