超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久操不卡,亚洲精品图区,精品综合久久久久久888蜜桃
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SPG3A/PE-Cy7 Conjugated antibody (bs-11759R-PE-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11759R-PE-Cy7
英文名稱 Rabbit Anti-SPG3A/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標記的G蛋白結合蛋白3抗體
別    名 Atlastin; AD FSP; atl1; ATLA1_HUMAN; Atlastin GTPase 1; Atlastin-1; Atlastin1; Brain specific GTP binding protein; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Guanylate binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG 3A; SPG3; SPG3A.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  結合蛋白  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPG3A/Atlastin (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.

Function:
GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.

Subunit:
Homooligomer. Interacts (via N-terminal region) withMAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 andRTN4 (via the transmembrane region). Interacts with SPAST;interaction is direct. May interact with TMED2. Interacts withREEP1.

Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell projection > axon.

Tissue Specificity:
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).

DISEASE:
Defects in ATL1 are the cause of spastic paraplegia autosomal dominant type 3 (SPG3) [MIM:182600]; also known as Strumpell-Lorrain syndrome. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Similarity:
Belongs to the GBP family. Atlastin subfamily.

Database links:

Entrez Gene: 51062 Human

Entrez Gene: 73991 Mouse

Entrez Gene: 362750 Rat

Entrez Gene: 535424 Cow

Omim: 606439 Human

SwissProt: Q58D72 Cow

SwissProt: Q8WXF7 Human

SwissProt: Q8BH66 Mouse

SwissProt: Q6PST4 Rat

Unigene: 584905 Human

Unigene: 474462 Mouse

Unigene: 135117 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 1区2区视频 | 老人把我添到了高潮A片 | 久久午夜羞羞影院免费观看 | 麻豆最新国产AV原创精品 | 制服丝袜第10页综合 | 亚洲视频无码一区 | 国产精品久久久国产 | 亚州中文字幕在线观看 | 8mav精品成人 | 亚洲伦理在线视频 | 四虎中文 | 日韩美女视频在线观看 | 免费无码A片一区二区三区天美 | 国产人妻一区二区三区四区五区六 | 亚洲精品四区麻豆文化传媒 | 亚洲高清精品中出 | 国产成人综合久久亚洲精品 | 国产精品偷伦视频免费观看了 | 久久靠逼 | 亚洲香蕉久久 | 久热RE这里精品视频在线6 | a级毛片毛片免费观看久潮 国产在线视频不卡一区二区三区 | 亚洲AV日韩精品一区二区三区 | 国产亚洲精品自在久久蜜TV | 国产真实野战在线视频 | 欧美成人国产精品视频 | av毛片在线观看地址 | 亚洲AV无码日韩AV无码网址 | 亚洲国产天堂久久国产91 | 日韩卡一卡二无线乱码新区仙踪林 | 福利视频一区二区三区 | 国产又黄又硬又湿又黄的 | 九色视频免费在线观看 | 亚洲一区二区二区久久成人婷婷 | 海角国精产品一区一区三区糖心 | 国产在线观看免费网站 | 黄页在线观看免费 | 欧美一级特黄aaaaaa在线看片 | 日本伊人精品一区二区三区介绍 | 中文字幕无码毛片免费看 | 精品久久久久久中文字幕2017 |