超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
在线黑人抽搐潮喷,日本乱码伦视频免费播放,91干干
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-DORFIN/Cy3 Conjugated antibody (bs-11778R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11778R-Cy3
英文名稱 Rabbit Anti-DORFIN/Cy3 Conjugated antibody
中文名稱 Cy3標記的環(huán)指蛋白19抗體
別    名 Dorfin; Double ring finger protein; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19A; p38; p38 protein; Ring finger protein 19; RING finger protein 19A; Ring IBR ring domain containing protein Dorfin; RN19A_HUMAN; RNF19; RNF19A; Ubce7ip2; UIP117; XYbp; AA032313; DKFZP566B1346.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  神經生物學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 91kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DORFIN/RNF19
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson’s disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.

Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.

Subcellular Location:
Membrane. Cytoplasm.

Tissue Specificity:
Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the RBR family. RNF19 subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.

Database links:

Entrez Gene: 25897 Human

Entrez Gene: 30945 Mouse

Entrez Gene: 654326 Pig

Entrez Gene: 362900 Rat

Entrez Gene: 540195 Cow

Entrez Gene: 475049 Dog

NCBI: 35493782 Human

Omim: 607119 Human

SwissProt: Q9NV58 Human

SwissProt: P50636 Mouse

SwissProt: Q2VJ60 Pig

Unigene: 292882 Human

Unigene: 5181 Mouse

Unigene: 94631 Pig



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 99热网址| 欧美人妻一区二区三区 | 国产盗摄XXXX视频XXXX | 日韩中文字幕免费在线观看 | 欧美成人aaa级毛片在线视频 | 国产精品7777777 | 日本又色又爽又黄的a片中文字幕 | 成人做爰 | 欧产日产国产蜜网站 | 91美女在线播放 | 亚洲成年人网址 | 精品无码人妻一区二区三区不卡 | 在线免费视频日韩 | 国产精品亚洲А∨无码播放不卡 | 国产AV无码国产AV毛片 | 一区二区三区在线视频播放 | 欧美综合影视自拍 | 国产a一区二区 | 十二生肖在线观看 | 国产一区二区三区四区五区入口 | 香港经典三级av在在线观看 | 婷婷激情综合色五月久久图片 | 国产吃瓜黑料一区二区 | 99久久夜色精品国产网站 | 久久天天躁狠狠躁夜夜2020老熟妇 | 两性午夜色视频免费网站 | 狠狠色狠狠色综合日日32 | 天天想夜夜操 | 男人操女人视频免费观看 | 色吧一区 | 免费一级黄色大片 | 好骚综合av | 日本高清无卡码一区二区久久 | 国模两腿玉门打开图无码 | 色综合久久无码中文字幕 | 理论片在线国产精品 | a级片免费在线播放 | 亚洲av中文无码乱人伦在线播放 | 久久国产不卡 | 99视频超级精品 | caoporn超碰进入页面 |