超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产小视频91,欧美VA亚洲VA在线观看日本 ,蜜臀69
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-DORFIN/Cy5 Conjugated antibody (bs-11778R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11778R-Cy5
英文名稱 Rabbit Anti-DORFIN/Cy5 Conjugated antibody
中文名稱 Cy5標記的環指蛋白19抗體
別    名 Dorfin; Double ring finger protein; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19A; p38; p38 protein; Ring finger protein 19; RING finger protein 19A; Ring IBR ring domain containing protein Dorfin; RN19A_HUMAN; RNF19; RNF19A; Ubce7ip2; UIP117; XYbp; AA032313; DKFZP566B1346.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  神經生物學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 91kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DORFIN/RNF19
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson’s disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.

Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.

Subcellular Location:
Membrane. Cytoplasm.

Tissue Specificity:
Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the RBR family. RNF19 subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.

Database links:

Entrez Gene: 25897 Human

Entrez Gene: 30945 Mouse

Entrez Gene: 654326 Pig

Entrez Gene: 362900 Rat

Entrez Gene: 540195 Cow

Entrez Gene: 475049 Dog

NCBI: 35493782 Human

Omim: 607119 Human

SwissProt: Q9NV58 Human

SwissProt: P50636 Mouse

SwissProt: Q2VJ60 Pig

Unigene: 292882 Human

Unigene: 5181 Mouse

Unigene: 94631 Pig



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 久久久久无码精品国产 | 亚洲AV综合日韩 | 少妇的bbw性大片 | 欧洲肉欲K8播放毛片 | 欧美成人精品二区三区99精品 | 亚洲乱码国产乱码精品精的特点 | 人妻无码αv中文字幕久久琪琪布 | 亚洲精品三 | 337p日本欧洲亚洲大胆张筱雨 | 国产v片| 日本在线免费观看 | 亚洲综合天堂婷婷五月 | 欧美性高潮 | 日b免费看 | 亚洲成人高清 | 神马免费午夜福利剧场 | 嗯快点别停舒服好爽受不了了 | 欧美在线三级艳情网站 | 色欲欲WWW成人网站 好男人社区WWW在线观看 | 青青青青久在线视频免费观看 | 宅男噜噜噜66在线观看 | 欧美日韩一区二区三区在线视频 | 亚洲午夜无码AV毛片久久 | 久久精品亚洲天堂 | av中文无码乱人伦 | 岛国无码av不卡一区二区 | 黄色一级片在线免费观看 | 天堂一区二区三区 | 四虎影视在线视频大全免费观看 | 秋霞鲁丝片成人无码 | 在线精品视频免费观看 | 视频一区免费 | 国产精品久久久久久久白皙女 | 欧美极品色午夜在线视频 | 亚洲人成一区 | 操操干干 | 中文字幕av免费在线观看 | 久久精品国产亚洲AV成人 | 欧美在线视频全部完 | 日韩片一区 | 国产在线精品一区二区中文 |