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Rabbit Anti-CGNL1/Gold Conjugated antibody (bs-13881R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-13881R-Gold
英文名稱 Rabbit Anti-CGNL1/Gold Conjugated antibody
中文名稱 膠體金標記的結(jié)蛋白樣蛋白CGNL1抗體
別    名 Cgnl1; CGNL1_HUMAN; Cingulin like 1; Cingulin-like protein 1; FLJ14957; JACOP; Junction-associated coiled-coil protein; KIAA1749; MGC138254; Paracingulin.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 149kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CGNL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

Function:
May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.

Subcellular Location:
Cell junction > tight junction. Localizes to the apical junction complex composed of tight and adherens junctions.

Tissue Specificity:
Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of adult brain.

DISEASE:
A chromosomal aberration involving CGNL1 is a cause of aromatase excess syndrome [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity. An inversion on inv(15)(q21.2;q21.3) moves the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region.

Similarity:
Belongs to the cingulin family.

Database links:

Entrez Gene: 84952 Human

Omim: 607856 Human

SwissProt: Q0VF96 Human

Unigene: 148989 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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