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Rabbit Anti-SIGIRR/PE-Cy5.5 Conjugated antibody (bs-7361R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7361R-PE-Cy5.5
英文名稱 Rabbit Anti-SIGIRR/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的IL-1相關Ig受體抗體
別    名 Ig IL1 related receptor; MGC110992; SIGIR_HUMAN; SIGIRR; Single Ig IL 1 related receptor; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single Ig IL1R Related Molecule; Single immunoglobulin and toll interleukin 1 receptor (TIR) domain; Single immunoglobulin and toll interleukin 1 receptor domain; Single immunoglobulin domain containing IL1R related protein; Single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR 8; TIR8; Toll/interleukin 1 receptor 8; Toll/interleukin-1 receptor 8.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIGIRR
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut.

Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Subcellular Location:
Membrane.

Tissue Specificity:
Mainly expressed in epithelial tissues such as kidney, lung and gut.

Similarity:
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.

Database links:

Entrez Gene: 59307 Human

Entrez Gene: 24058 Mouse

Entrez Gene: 309106 Rat

Omim: 605478 Human

SwissProt: Q6IA17 Human

SwissProt: Q9JLZ8 Mouse

SwissProt: Q4V892 Rat

Unigene: 501624 Human

Unigene: 38017 Mouse

Unigene: 16525 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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