超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产69精品久久久久久,日本成片,日韩视频精品一区
Rabbit Anti-ACCN2/PE Conjugated antibody (bs-12128R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-12128R-PE
英文名稱 Rabbit Anti-ACCN2/PE Conjugated antibody
中文名稱 PE標(biāo)記的腦鈉通道蛋白2抗體
別    名 ASIC1; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; Acid-sensing ion channel 1; AI843610; ASIC1_HUMAN; Acid-sensing ion channel 1; Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2; BNAC2.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ACCN2/ASIC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Acid sensing ion channel ASIC1 is present in brain as a 4.3-kb transcript with localization to rat dorsal root ganglia. In situ hybridization of rat brain suggests that ASIC1 is most abundant in the main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei and cerebellum. ASIC1 and H+-gated currents may contribute to the development of fear and anxiety. ASIC2, also designated amiloride-sensitive cation channel 1, neuronal (ACCN1), mammalian degenerin, BNAC1 (MDEG) and brain Na+ channel 1, mediates the normal detection of light touch. ASIC2 mRNA is abundant in brain, specifically in neurons. ASIC2 is expressed as 2.7- and 3.7-kb transcripts in brain and spinal cord tissues. ASIC3, also designated SLNAC1 and TNaC1, mediates detection of lasting pH changes and is involved in modulating moderate- to high-intensity pain sensation. ASIC4, also designated ACCN4 and BNAC4, is abundant in pituitary gland and is also present in the inner ear.

Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Subunit:
Homotrimer or heterotrimer with other ASIC proteins. Interacts with STOM and ASIC2. Interacts with PRKCABP.

Subcellular Location:
Cell membrane. Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.

Tissue Specificity:
Expressed in most or all neurons.

Post-translational modifications:
Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.

Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.
ACCN2 subfamily.

Database links:

Entrez Gene: 41 Human

Entrez Gene: 11419 Mouse

Entrez Gene: 79123 Rat

Omim: 602866 Human

SwissProt: P78348 Human

SwissProt: Q6NXK8 Mouse

SwissProt: P55926 Rat

Unigene: 274361 Human

Unigene: 440107 Mouse

Unigene: 37385 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 99在线精品视频免费观看软件 | 久久999精品久久久 h成人在线观看 | 区二区欧美性插b在线视频网站 | 黄色视频毛片 | 久久AV高潮AV无码AV喷吹 | 成年人网站国产 | 午夜天堂成人欧美www无码 | 免费a片在线网站大全 | 免费看黄色的网站 | 国产午夜无码片在线观看 | 亚洲精品视频在线免费播放 | 国产成年人小视频 | 奇色影视 | 含着她的花蒂啃到高潮在线观看 | 人人爽久久涩噜噜噜丁香 | caoporn超碰最新地址进入 | 免费观看国产精品视频 | 国产精品视频免费看 | 又粗又大又黄又硬又爽免费看 | 亚洲美女在线播放 | 看亚洲毛片 | 亚洲综合中文字幕在线观看 | 欧美亚洲国产日韩 | 免费女人18毛片A级毛片视频 | 高清无码中字在线一区二区 | 日本黄色片免费 | 久久久久狠狠高潮亚洲精品 | 国产无套露脸视频在线观看 | 中文字幕成熟丰满人妻 | 亚洲一区日韩 | yw193.com尤物在线 | 黑人玩弄人妻中文在线 | 桃子视频在线播放WWW | 欧美黑人又粗又大又爽免费 | 老司机免费视频一区二区三区 | 亚洲高清无码在线观看 | 仙踪林久久久久久久999 | 欧美亚洲另类激情另类 | 午夜久久国产 | 992tv在线观看视频 | 亚洲地区天堂网 |