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Rabbit Anti-BP1/BF350 Conjugated antibody (bs-12307R-BF350)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12307R-BF350
英文名稱 Rabbit Anti-BP1/BF350 Conjugated antibody
中文名稱 BF350標記的氨肽酶A抗體
別    名 Aminopeptidase A; AMPE_HUMAN; AP-A; APA; CD249; CD 249; Differentiation antigen gp160; EAP; EC 3.4.11.7; ENPEP; Glutamyl aminopeptidase; Gp160; Ly51; Ly51/6C3 antigen.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  發育生物學  干細胞  淋巴細胞  b-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 109kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Aminopeptidase A
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Aminopeptidase A, also designated APA, gp160 human kidney differentiation antigen, glutamyl aminopeptidase, or enpep, is a differentiation-related kidney glycoprotein. As a cell surface, zinc-dependent metalloprotease, Aminopepti-dase A specifically cleaves amino-terminal acidic residues from peptide substrates such as Angiotensin II. APA is expressed on the surface of epithelial cells of the glomerulus and proximal tubule cells of the human nephron, where it may mediate the constitutive trafficking of Glut4-containing vesicles. These Glut4-containing vesicles are tissue-specific secretory-like microsomal structures that mediate insulin-dependent translocation of GLUT4 to the cell surface in fat and muscle cells. Mutations in the gp160/APA gene, including loss of protein expression or enzymatic activity, occur in 20% of primary clear cell renal carcinomas.

Function:
Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.

Similarity:
Belongs to the peptidase M1 family.

Database links:

Entrez Gene: 2028 Human

Entrez Gene: 13809 Mouse

Entrez Gene: 397080 Pig

Entrez Gene: 64017 Rat

Entrez Gene: 504350 Cow

Omim: 138297 Human

SwissProt: Q32LQ0 Cow

SwissProt: Q07075 Human

SwissProt: P16406 Mouse

SwissProt: Q95334 Pig

SwissProt: P50123 Rat

Unigene: 435765 Human

Unigene: 1193 Mouse

Unigene: 162610 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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