超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久精品AⅤ无码中文字字幕重口,久久精品国产亚洲欧美成人,成人国产综合
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Prickle/Gold Conjugated antibody (bs-12411R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-12411R-Gold
英文名稱 Rabbit Anti-Prickle/Gold Conjugated antibody
中文名稱 膠體金標記的刺痛感蛋白抗體
別    名 FLJ31627; FLJ31937; MGC138902; MGC138903; EPM1B; Prickle 1; Prickle homolog 1 (Drosophila); Prickle like protein 1; Prickle-like 1; Prickle1; REST-Interacting LIM Domain Protein; REST/NRSF interacting LIM domain protein 1; RILP; PRIC1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Prickle
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Prickle1 is an 831 amino acid protein that contains one PET domain and three LIM zinc-binding domains and localizes to the cytoplasm, as well as to the nuclear membrane. Expressed at higher levels in placenta and at lower levels in liver, brain, kidney, lung and pancreas, Prickle1 is thought to function as a nuclear receptor that interacts with NRSF, a silencer protein that binds the DNA sequence element NRSE (neuron-restrictive silencer element). Defects in the gene encoding Prickle1 are associated with autosomal recessive progressive myoclonic epilepsy-1B, which is characterized by quick jerks of the arms, shoulders or legs. The gene encoding Prickle1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.

Function:
Prickle is a LIM domain protein that appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors. The human protein is a 831 amino acid protein containing 3 N-terminal LIM domains and 3 C-terminal nuclear localization signals. It also contains 4 N-glycosylation sites, 2 PKA phosphorylation sites, and a C-terminal CIIS prenylation motif.

Subunit:
Interacts with REST.

Subcellular Location:
Nuclear Membrane

Tissue Specificity:
Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).

DISEASE:
Defects in PRICKLE1 are the cause of progressive myoclonic epilepsy type 1B (EPM1B) [MIM:612437]. EPM1B is an autosomal recessive disorder characterized by myoclonus that progresses in severity over time, tonic-clonic seizures and ataxia.
Defects in PRICKLE1 may be a cause of susceptibility to neural tube defects (NTD) [MIM:182940]. Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.

Similarity:
Belongs to the prickle / espinas / testin family.
Contains 3 LIM zinc-binding domains.
Contains 1 PET domain.

Database links:

Entrez Gene: 144165 Human

Entrez Gene: 106042 Mouse

Entrez Gene: 315259 Rat

Omim: 608500 Human

SwissProt: Q14C83 Human

SwissProt: Q96MT3 Human

SwissProt: Q3U5C7 Mouse

SwissProt: Q71QF9 Rat

Unigene: 524348 Human

Unigene: 150314 Mouse

Unigene: 86665 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产亚洲综合久久系列 | 裸体超大乳抖乳露双乳呻吟 | 国产免费91视频 | 中国产xxxxa片在线观看 | 91久久夜色精品国产按摩 | 欧美精品一区二区免费 | 一二三四区在线视频 | 无码伊人久久大杳蕉中文无码 | 日本欧美成人 | 美丽的姑娘免费播放影视大全 | 精品一区影院 | 亚洲片在线观看 | 亚洲国产的精品太乱码一区二区 | 少妇搡BBBB搡BBB搡野外 | 免费XXXX大片| 中文字幕精品无码综合网 | 欧美在线观看视频一区二区 | 国产热A欧美热A在线视频 | 亚洲成a人片在线不卡一二三区 | 亚洲精品中文字幕久久久久 | 99久久国产综合精品女图图等你 | 人妻av一区二区三区精品 | 欧美国产成人久久精品 | 国产一级片免费 | 99久久夜色精品国产网站 | 国产毛片久久久久久蜜臂媒 | 亚洲精品无码一区二区三区在线高 | 久久69精品久久久久久国产越南 | 人与禽一级一级毛片 | 欧美高潮喷水大叫 | 亚洲av图片 | 日韩免费看片 | 精品久久久久久无码人妻蜜桃 | 一级高清视频 | 在线观看成人毛片 | 亚洲综合激情五月丁香六月 | 99热都是精品久久久久久 | 男女啪啪抽搐呻吟高潮动态图 | 亚洲av成人一区二区三区观看 | 国产精品视频成人 | 久久久久久久极品内射 |