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      Rabbit Anti-Kv1.4/Gold Conjugated antibody (bs-12183R-Gold)
      訂購熱線:400-901-9800
      訂購郵箱:sales@bioss.com.cn
      訂購QQ:  400-901-9800
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      說 明 書: 100ul(10nm  15nm  35nm
      100ul/2980.00元
      大包裝/詢價
      產品編號 bs-12183R-Gold
      英文名稱 Rabbit Anti-Kv1.4/Gold Conjugated antibody
      中文名稱 膠體金標記的電壓門控性鉀通道蛋白Kv1.4抗體
      別    名 Voltage gated K+ channel HuKII; cardiac potassium channel; fetal skeletal muscle potassium channel; HBK 4; HBK4; HK 1; HK1; HPCN 2; HPCN2; HUK II; HUKII; KCNA 4; KCNA 8; KCNA4; KCNA4_HUMAN; KCNA4L; KCNA8; kv1.4; PCN 2; PCN2; potassium channel 2; potassium channel KCNA4; potassium channel protein; Potassium voltage gated channel shaker related subfamily member 4; Potassium voltage gated channel subfamily A member 4; potassium voltage-gated channel shaker-related subfamily member 4-like; Potassium voltage-gated channel subfamily A member 4; rapidly inactivating potassium channel; Shaker related potassium channel Kv1.4; shaker-related potassium channel Kv1.4; type A potassium channel; Voltage gated potassium channel HBK4; Voltage gated potassium channel HK1; Voltage gated potassium channel subunit Kv1.4; Voltage-gated K(+) channel HuKII; voltage-gated potassium channel; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; voltage-gated potassium channel protein Kv1.4; Voltage-gated potassium channel subunit Kv1.4.   
      規格價格 100ul/2980元 購買        大包裝/詢價
      說 明 書 100ul(10nm  15nm  35nm
      研究領域 神經生物學  通道蛋白  細胞膜受體  
      抗體來源 Rabbit
      克隆類型 Polyclonal
      交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
      產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量 73kDa
      性    狀 Lyophilized or Liquid
      濃    度 0.4mg/ml
      免 疫 原 KLH conjugated synthetic peptide derived from human Kv1.4
      亞    型 IgG
      純化方法 affinity purified by Protein A
      儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
      保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
      產品介紹 background:
      Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.

      Function:
      Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

      Subunit:
      Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with SIGMAR1 (By similarity). Part of a complex containing KCNA1, KCNAB1 and LGI1 (By similarity).

      Subcellular Location:
      Membrane; Multi-pass membrane protein.

      Similarity:
      Belongs to the potassium channel family.
      A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.

      Database links:

      Entrez Gene: 3739 Human

      Entrez Gene: 16492 Mouse

      Entrez Gene: 25469 Rat

      Omim: 176266 Human

      SwissProt: P22459 Human

      SwissProt: Q61423 Mouse

      SwissProt: P15385 Rat

      Unigene: 592002 Human

      Unigene: 142718 Mouse

      Unigene: 9884 Rat



      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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