超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲一区中文在线,日韩成人免费中文字幕,国产70老熟女重口小伙子
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-BAD(Ser91)/Cy3 Conjugated antibody (bs-12567R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12567R-Cy3
英文名稱 Rabbit Anti-phospho-BAD(Ser91)/Cy3 Conjugated antibody
中文名稱 Cy3標記的磷酸化相關死亡促進因子抗體
別    名 Bad (phospho S91); p-Bad (phospho S91); BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  細胞凋亡  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human BAD around the phosphorylation site of Ser91
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform. This antibody recognise the phosphorylation site of human Ser75, mouse Ser111, rat Ser112.

Function:
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

Subcellular Location:
Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm.

Tissue Specificity:
Expressed in a wide variety of tissues.

Post-translational modifications:
Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity.
Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Ser-75 is phosphorylated by AKT/PKB, protein kinase A and PIM2.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 572 Human

Omim: 603167 Human

SwissProt: Q92934 Human

Unigene: 370254 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品一区二区精品视频免费看 | 玩偶国产一区二区在线观看 | 老司机一区二区 | 伊人成人高清在线 | 97干视频| 国产免费一区二区三区播放 | gay男同帅哥网站在线观看 | 国产婷婷一区二区 | 国产伦精品 | 国产精品-去看片 | 日韩在线视频观看免费网站 | 国产精品综合AV一区二区国产馆 | 亚洲啊v在线观看 | 欧美精品一区二区三区久久久竹菊 | 健身教练啪啪偷拍一区二区 | 国产精品久久毛片av大全日韩 | 在线一区不卡 | 视频免费观看在线 | 欧美久久久久久久 | 亚洲日韩av无码一本到 | 伊人精品久久 | 日韩一级成人 | 无码AV中文字幕出轨人妻 | 性做久久久久久久久 | 国产精品涩涩涩视频网站 | 日韩中文字幕免费在线观看 | 久久成年片色大黄全免费网站 | 精品欧美日韩国产日漫一区不卡 | 亚洲一级无毛 | 一区二区三区影视 | 大地资源在线观看免费中文版 | 欧美成人国产精品视频 | 青青青青久在线视频免费观看 | 日韩亚洲制服丝袜中文字幕 | 欧美日韩综合精品 | 本道综合精品 | 开妇小嫩苞调教HHH嗯啊MTV | 人人干人人爱 | 国产强奷女交警在线播放 | 精品无码一区二区三区 | 色94色欧美sute亚洲线路二 |