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Rabbit Anti-APOA1BP/AI-BP/RBITC Conjugated antibody (bs-12491R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12491R-RBITC
英文名稱 Rabbit Anti-APOA1BP/AI-BP/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的載脂蛋白A1結合蛋白抗體抗體
別    名 AI BP; AIBP; ApoA I binding protein; Apolipoprotein A I binding protein; MGC119143; MGC119144; MGC119145; YjeF N terminal domain containing protein 1; YJEFN1; NNRE_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Chimpanzee, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human APOA1BP/AI-BP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Apolipoproteins are protein components of plasma lipoproteins. Apolipoprotein A-I (ApoA1) promotes cholesterol efflux from tissues to the liver for excretion. ApoA1 is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase, which is responsible for the formation of most plasma cholesteryl esters. AI-BP (Apolipoprotein A-I-binding protein), also known as YjeF N-terminal domain-containing protein 1, is a 288 amino acid secreted protein that binds ApoA1, ApoA2 and HDL. Individuals with impaired renal function show an increased rate of AI-BP excretion, indicating that it is normally reabsorbed within the kidney tubules. AI-BP belongs to the YjeF N-terminal domain protein family, which includes proteins that are frequently involved in oogenesis and spermatogenesis. There are two isoforms of AI-BP that are produced as a result of alternative splicing events.

Function:
APOA1BP interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I.

Subunit:
Homodimer (By similarity). Interacts with APOA1 and APOA2.

Subcellular Location:
Secreted

Tissue Specificity:
Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).

Post-translational modifications:
Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation (By similarity).

Similarity:
Belongs to the nnrE/AIBP family.
Contains 1 YjeF N-terminal domain.

Database links:

Entrez Gene: 128240 Human

Entrez Gene: 246703 Mouse

Entrez Gene: 780405 Pig

Entrez Gene: 295229 Rat

Omim: 608862 Human

SwissProt: Q6QRN6 Cow

SwissProt: E2QRY6 Dog

SwissProt: Q8NCW5 Human

SwissProt: Q8K4Z3 Mouse

SwissProt: Q0PIT9 Pig

SwissProt: B0BNM1 Rat

Unigene: 528320 Human

Unigene: 205996 Mouse

Unigene: 14886 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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