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Rabbit Anti-phospho-AQP2 (Ser256)/AP Conjugated antibody (bs-12507R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12507R-AP
英文名稱 Rabbit Anti-phospho-AQP2 (Ser256)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化水通道蛋白2抗體
別    名 Aquaporin 2 (phospho S256); Aquaporin 2 (phospho Ser256); p-Aquaporin 2 (phospho S256); p-Aquaporin 2 (S256); ADH water channel; AQP 2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD; AQP2_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  信號轉導  通道蛋白  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Dog,  (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Monkey, )
產品應用 WB=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human AQP2 around the phosphorylation site of Ser256
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation, and the secretion and reabsorption of cerebrospinal fluid and aqueous humor.

Function:
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Subcellular Location:
Apical cell membrane. Cytoplasmic vesicle membrane. Shuttles from vesicles to the apical membrane.

Tissue Specificity:
Expressed in renal collecting tubules.

Post-translational modifications:
Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.

DISEASE:
Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.

Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.

Database links:

Entrez Gene: 359 Human

Entrez Gene: 11827 Mouse

Entrez Gene: 25386 Rat

Omim: 107777 Human

SwissProt: P41181 Human

SwissProt: P56402 Mouse

SwissProt: P34080 Rat

Unigene: 130730 Human

Unigene: 20206 Mouse

Unigene: 90076 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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