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Rabbit Anti-RRAGC/BF350 Conjugated antibody (bs-10097R-BF350)
訂購熱線:400-901-9800
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訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-10097R-BF350
英文名稱 Rabbit Anti-RRAGC/BF350 Conjugated antibody
中文名稱 BF350標記的RAS相關GTP結合蛋白C抗體
別    名 RAGC; TIB929; YGR163W; GTPase interacting protein 2; GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; Ras related GTP binding C; Ras-related GTP-binding protein C; RP23 29H22.4; RRAGC; RRAGC_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  染色質和核信號  信號轉導  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RRAGC
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].

Function:
Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.

Subunit:
Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB.

Subcellular Location:
Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.

Similarity:
Belongs to the GTR/RAG GTP-binding protein family.

Database links:

Entrez Gene: 64121 Human

Entrez Gene: 54170 Mouse

Entrez Gene: 100528436 Pig

Entrez Gene: 298514 Rat

Omim: 608267 Human

SwissProt: Q9HB90 Human

SwissProt: Q99K70 Mouse

Unigene: 532461 Human

Unigene: 220922 Mouse

Unigene: 473825 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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