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Rabbit Anti-GCP3/BF488 Conjugated antibody (bs-13277R-BF488)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-13277R-BF488
英文名稱 Rabbit Anti-GCP3/BF488 Conjugated antibody
中文名稱 BF488標記的γ-微管蛋白復合物GCP3抗體
別    名 Gamma tubulin complex component 3; Gamma-ring complex protein 104 kDa; Gamma-tubulin complex component 3; GCP-3; GCP3; GCP3_HUMAN; h104p; hGCP3; hGrip104; hSpc98; SPBC98; Spc98p; Spindle pole body protein Spc98 homolog; TUBGCP3; Tubulin gamma complex associated protein 3.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Cow, Sheep, Xenopus laevis)
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 104kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GCP3/Gamma-tubulin complex component 3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The Gamma-Tubulin complex is composed of Gamma Tubulin and the Gamma-Tubulin complex-associated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. Gamma-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the Gamma-Tubulin complex. GCP3 (Gamma-Tubulin complex component 3), also known as TUBGCP3 or SPBC98, localizes to the centrosome and is a ubiquitously expressed 907 amino acid member of the Gamma-Tubulin complex. Like GCP2 and Gamma Tubulin, GCP3 is conserved in all eukaryotes, suggesting that it is part of a core unit involved in eukaryotic microtubule nucleation. Three isoforms of GCP3 exist due to alternative splicing events.

Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Subunit:
Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the GCP family.

Database links:

Entrez Gene: 10426 Human

Entrez Gene: 259279 Mouse

SwissProt: Q96CW5 Human

SwissProt: P58854 Mouse

Unigene: 224152 Huma



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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