超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
成人一级黄色大片,色婷婷久久久亚洲一区二区三区,日产一二三四五六七区麻豆
Rabbit Anti-GFI1/PE Conjugated antibody (bs-13337R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-13337R-PE
英文名稱 Rabbit Anti-GFI1/PE Conjugated antibody
中文名稱 PE標(biāo)記的自主生長(zhǎng)因子GFI1抗體
別    名 GFI 1; GFI1; GFI-1; GFI1_HUMAN; Growth factor independence 1; growth factor independent 1; Growth factor independent protein 1; SCN2; Zinc finger protein 163; Zinc finger protein Gfi 1; Zinc finger protein Gfi-1; Zinc finger protein Gfi1; ZNF 163; ZNF163.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, Xenopus laevis)
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GFI1/ZNF163
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Growth factor independent 1 (Gfi-1) is a transcriptional repressor that specifically binds to the DNA consensus sequence TAAATCAC(A/T)GCA. The carboxy-terminus of Gfi-1 contains six C2H2-type zinc finger motifs, and zinc fingers 3, 4 and 5 are required for the binding of Gfi-1 to its DNA binding site. Gfi-1 also contains a 20 amino acid SNAG domain which mediates transcriptional repression. It represses Bax at the mRNA and protein levels, resulting in the inhibition of cell death. Gfi1 is expressed outside the lymphoid system in granulocytes and activated macrophages. Gfi-1B, a related protein, is a transcriptional repressor primarily expressed in bone marrow and spleen. Gfi-1B is a direct repressor of the p21 promoter and the Socs 1 and 3 promoters. The genes encoding human Gfi-1 and Gfi-1B map to chromosome 1p22 and 9q34.3, respectively.

Function:
Transcription factor regulating the expression of genes active during S-phase of the cell cycle in hematopoietic cells. Represses ELA2 transcription.

Subunit:
Interacts with U2AF1L4. Component of RCOR-GFI-KDM1A-HDAC complexes. Interacts directly with RCOR1, KDM1A and HDAC2 (By similarity). Also interacts with HDAC1. Interacts (via the zinc-finger domain) with ARIH2; the interaction prevents GFI1 ubiquitination and proteasomal degradation. Interacts with PIAS3; the interaction relieves the inhibitory effect of PIAS3 on STAT3-mediated transcriptional activity. Forms a complex with EHMT2 and HDAC1 to promote 'Lys-9' dimethylation of H3 (H3K9Me2) and repress expression of target genes. Interacts directly with EHMT2. Component of the GFI1-AJUBA-HDAC1 repressor complex. Interacts directly with AJUBA (via ITS LIM domains); the interaction results in the HDAC-dependent corepression of a subset of GFI1 target genes and, occurs independently of the SNAG domain. Interacts with SPI1; the interaction inhibits SPI1 transcriptional activity and represses SPI1-regulated macrophage-specific genes required for proper granulocyte development. Interacts with RUNX1T1; the interaction represses HDAC-mediated transcriptional activity. Interacts with RELA; the interaction occurs on liposaccharide (LPS) stimulation and controls RELA DNA binding activity and regulates endotoxin-mediated TOLL-like receptor inflammatory response. Interacts (via the C-terminal zinc fingers) with ZBTB17; the interaction results in the recruitment of GFI1 to the CDKN1A/p21 and CDKN1B promoters and repression of transcription.

Subcellular Location:
Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

Post-translational modifications:
Ubiquitinated.

DISEASE:
Defects in GFI1 are a cause of neutropenia severe congenital autosomal dominant type 2 (SCN2) [MIM:613107]. SCN2 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
Defects in GFI1 are a cause of dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) [MIM:607847]. NI-CINA is a relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients.

Similarity:
Contains 6 C2H2-type zinc fingers.

Database links:

Entrez Gene: 2672 Human

Entrez Gene: 14581 Mouse

Entrez Gene: 24388 Rat

Omim: 600871 Human

SwissProt: Q99684 Human

SwissProt: P70338 Mouse

SwissProt: Q07120 Rat

Unigene: 73172 Human

Unigene: 2078 Mouse

Unigene: 453139 Mouse

Unigene: 10935 Ra



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
主站蜘蛛池模板: 熟睡人妻被讨厌的公侵犯 | 狠狠插久久综合网最新章节 | 亚洲伊人久久精品影院一美女洗澡 | 久久国产精99精产国高潮 | 亚洲444KKKK在线观看无码 | 日韩伦理中文字幕 | 国产精品自拍av | www成人 | 韩国三级按摩 | 96精品成人无码A片观看金桔 | 中国A级毛片免费观看 | 黄色aⅴ免费片网站大全 | 94一欧美一setu | 国产第一页视频在线播放 | 国产伦子沙发午休系列资源曝光 | 老鸭窝男人的天堂 | 中日韩欧美在线观看 | 国产伦精品久久久一区二区三区 | 韩国三级按摩 | 爆乳一区二区三区无码 | 成人网站免费观看 | av优选在线观看 | FREEEⅩXX性欧美HD浪妇 | 久久精品666 | 国产精品一区二区三区四区五区 | 521色香蕉网站在线观看 | 久一在线视频 | 91污视频在线观看 | 色香欲综合成人免费视频 | 国产精品一区久久看 | 欧美一区内射最近更新 | 激情草逼 | 日本少妇ⅹxxhd第一次 | 成年女人免费又黄又爽视频 | 亚洲日韩看片无码超清 | 亚洲第一视频 | 成A人影片免费观看日本 | 狠狠操福利视频 | 成人国产精品入口免费视频 | 国产成人综合亚洲欧美 | 久久97精品久久久久久久不卡 |