超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
大狠狠大臿蕉香蕉大视频,97人人添人澡人人爽超碰 ,精品国产经典三级在线看
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-URP2/Kindlin-3/BF555 Conjugated antibody (bs-13738R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-13738R-BF555
英文名稱 Rabbit Anti-URP2/Kindlin-3/BF555 Conjugated antibody
中文名稱 BF555標記的整合素結合性信號分子抗體
別    名 Fermitin family homolog 3; Fermitin family member 3; FERMT3; Kind3; Kindlin 3; Kindlin-3; Kindlin3; MGC10966; MIG 2; MIG2 like protein; MIG2-like protein; MIG2B; Unc 112 related protein 2; Unc-112-related protein 2; UNC112C; URP2_HUMAN; URP2SF.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human URP2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Kindlin-3 is a 667 amino acid protein that localizes to both the cell membrane and the cytoplasm and contains one PH domain and one FERM domain. Expressed at high levels in lymph node tissue and at lower levels in spleen, thymus, stomach, placenta, lung, testis and small intestine, Kindlin-3 is thought to be involved in cell adhesion events and may play a role in apoptosis. Kindlin-3 is overexpressed in B-cell malignancies, suggesting that, via its ability to affect cell adhesion, Kindlin-3 may participate in tumor transformation and metastasis. Two isforms of Kindlin-3, designated short and long, exist due to alternative splicing events.

Function:
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.

Subcellular Location:
Cell projection; podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.

Tissue Specificity:
Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.

DISEASE:
Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes.

Similarity:
Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 83706 Human

Entrez Gene: 525159 Cow

Entrez Gene: 108101 Mouse

Entrez Gene: 309186 Rat

Omim: 607901 Human

SwissProt: Q32LP0 Cow

SwissProt: Q86UX7 Human

SwissProt: Q8K1B8 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产亚洲美女精品久久久2020 | 久久亚洲影院 | 国产偷窥洗澡视频 | 婷婷五月天.com | 久久久亚洲一区二区三区 | 大地在线资源 | 国产精品JK白丝AV网站 | 2020日日夜夜噜噜噜com | 女邻居丰满的奶水 | 狠狠操狠狠摸 | 国产精品亚洲精品一区二区三区 | 在线观看免费毛片 | 国产无遮挡又黄又大又爽 | 中文字幕色一区二区 | 一区二区三区四区免费视频 | 欧美性色网站 | 午夜国产情侣在线播放 | 在线观看免费视频91 | 国产精品免费久久影 | 亚洲国产精品女人久久久 | av无码理论片在线观看免费网站 | 国产免费成人av | 欧美激情网 | 中文成人无码精品久久久不卡 | 亚洲综合欧美日韩狠狠色 | 精品国产乱码久久久久禁果 | 人妻少妇精品视中文字幕国语 | 999精品欧美一区二区三区黑人 | 粉嫩av一区二区 | 欧美色图国产精品 | 四虎海外网址 | 一级毛片影视 | 国产精品成人免费一区久久羞羞 | 福利一级片 | 下属新婚人妻紧窄 | 日韩一级片免费视频 | 欧美精品一区二区三区中文字幕 | 久久99精品久久久久久手机免费 | 美国久久精品 | 成人依依网站亚洲综合久 | 成人国产精品久久久久久亚洲 |