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Rabbit Anti-EIF3S2/PE-Cy3 Conjugated antibody (bs-14544R-PE-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-14544R-PE-Cy3
英文名稱 Rabbit Anti-EIF3S2/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的eIF3β蛋白抗體
別    名 eIF-3-beta; eIF3 beta; eIF3 p36; eIF3-beta; eIF3-p36; eIF3i; EIF3I_HUMAN; EIF3S2; EIF3S2, formerly; Eukaryotic translation initiation factor 3 subunit 2; Eukaryotic translation initiation factor 3 subunit 2 beta; Eukaryotic translation initiation factor 3 subunit I; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD; eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa; eukaryotic translation initiation factor 3, subunit 2, formerly; eukaryotic translation initiation factor 3, subunit I; Predicted protein of HQ2242; PRO2242; TGF beta receptor interacting protein 1; TGF-beta receptor-interacting protein 1; TGFbeta receptor interacting protein 1; TGFbeta receptor-interacting protein 1; TRIP 1; TRIP-1; TRIP1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  轉運蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EIF3S2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3 alpha, eIF3 beta, eIF3 gamma, eIF3 delta, eIF3 epsilon, eIF3 omega, eIF3 eta, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.

Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylated by TGF-beta type II receptor.

Similarity:
Belongs to the eIF-3 subunit I family.
Contains 5 WD repeats.

Database links:

Entrez Gene: 8668 Human

Entrez Gene: 419653 Chicken

Entrez Gene: 521747 Cow

Entrez Gene: 54709 Mouse

Entrez Gene: 100008959 Rabbit

Entrez Gene: 682390 Rat

Entrez Gene: 447488 Xenopus laevis

Entrez Gene: 548498 Xenopus tropicalis

Omim: 603911 Human

SwissProt: Q5E966 Cow

SwissProt: Q13347 Human

SwissProt: Q9QZD9 Mouse

SwissProt: Q5IH81 Rabbit

SwissProt: B0BNA7 Rat

SwissProt: Q66J51 Xenopus laevis

SwissProt: Q5EBE8 Xenopus tropicalis

Unigene: 530096 Human

Unigene: 250874 Mouse

Unigene: 162577 Rat

Unigene: 77336 Xenopus laevis



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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