超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
久草论坛,欧美大陆日韩,曰本性l交片视频视频
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Rasgrp1/Cy7 Conjugated antibody (bs-10436R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10436R-Cy7
英文名稱 Rabbit Anti-Rasgrp1/Cy7 Conjugated antibody
中文名稱 Cy7標記的Ras蛋白特異鳥嘌呤核苷酸釋放因子1抗體
別    名 Calcium and DAG-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CALDAG-GEFII; Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A; hRasGRP1; Ras activator RasGRP; RAS guanyl nucleotide releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl releasing protein 1; RASGRP; RASGRP1; GRP1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  神經(jīng)生物學  信號轉(zhuǎn)導  結(jié)合蛋白  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Rabbit, )
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Rasgrp1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].

Function:
RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas.

Subunit:
Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1.

Subcellular Location:
Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus. Found in membrane fraction. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor.

Tissue Specificity:
Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level).

Post-translational modifications:
Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

Similarity:
Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Ras-GEF domain.

Database links:

Entrez Gene: 10125 Human

Entrez Gene: 19419 Mouse

Omim: 603962 Human

SwissProt: O95267 Human

SwissProt: Q9Z1S3 Mouse

Unigene: 591127 Human

Unigene: 42150 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 亚洲欧美视频在线观看 | 欧美激情极品久久久久久 | 日韩av免费| 亚洲日韩看片无码AV | YY111111少妇无码理论片 | 九九久久婷婷 | 久久综合香蕉 | 国产人成在线视频免费播放 | 99这里有精品热视频 | 精品九九 | 高潮流白浆潮喷在线播放视频 | 成人国产免费 | 亚洲男女内射在线播放 | 黄色大片免费观看视频 | 国产精品久久久久久久久婷婷 | 佐山爱痴汉视频一区二区三区 | 日本熟妇无码色视频网站VR | 久久久久久逼 | 亚洲国产欧美一区二区三区久久 | 成人区一区二区三区 | 久久久久久这里只有精品 | 佐山爱国产在线一区 | 国产免费一区二区三区在线网站 | 最新国产一级片 | 99久久亚洲精品蜜臀 | 色网在线播放 | 国产综合视频一区二区三区免费 | 欧美日韩一本的免费高清视频 | 精品欧美视频 | 亚洲精品久久久久久久久久吃药 | 99av精品孕妇在线 | 欧美日韩激情网 | 欧美日本一区视频免费 | 中文字幕av三区 | 久久国产精99精产国高潮 | 亚洲天堂久久新 | 精品亚洲va在线va天堂资源站 | chinese猛男自慰gv网站 | 欧美视频在线看 | 日韩毛片在线看 | 免费网站在线观看黄 |