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Rabbit Anti-FLG2/BF488 Conjugated antibody (bs-16100R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16100R-BF488
英文名稱 Rabbit Anti-FLG2/BF488 Conjugated antibody
中文名稱 BF488標記的FLG2蛋白抗體
別    名 FILA2_HUMAN; Filaggrin-2; FLG-2; FLG2; Ifapsoriasin; Intermediate filament-associated and psoriasis-susceptibility protein.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 248kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FLG2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Profilaggrin is a large, insoluble, highly phosphorylated precursor protein and major component of keratohyalin granules in the living cells of the epidermis. During terminal differentiation of the epidermis, profilaggrin is proteolytically processed into active Filaggrin molecules that promote aggregation and disulfide-bond formation of keratin intermediate filaments. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that Filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery. Filaggrin 2, also known as FLG2, Ifapsoriasin or IFPS (intermediate filament-associated and psoriasis-susceptibility protein), is a 2,391 amino acid protein that shares common structural features with Filaggrin. Filaggrin 2 contains ten Filaggrin repeats, two EF-hand domains and belongs to both the S-100 and S100-fused protein families.

Similarity:
Belongs to the S100-fused protein family.
In the N-terminal section; belongs to the S-100 family.
Contains 2 EF-hand domains.
Contains 10 filaggrin repeats.

Database links:

Entrez Gene: 388698 Human

SwissProt: Q5D862 Human

Unigene: 156124 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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