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Rabbit Anti-cAMP-receptor protein/BF488 Conjugated antibody (bs-12707R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12707R-BF488
英文名稱 Rabbit Anti-cAMP-receptor protein/BF488 Conjugated antibody
中文名稱 BF488標記的腺苷受體蛋白抗體
別    名 CRP_ECOLI; cAMP-activated global transcriptional regulator CRP; Catabolite activator protein; CAP; Catabolite gene activator; cAMP receptor protein; CRP; cAMP regulatory protein.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  轉錄調節因子  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human cAMP-receptor protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Escherichia coli contains more than 250 known promoters that must be activated prior to transcription. cAMP receptor protein (crp), also known as cAMP regulatory protein and catabolite gene activator, is a 210 amino acid E. coli protein that complexes with cyclic AMP and binds to specific DNA sites near the promoter, resulting in homodimeric transcription activation of more than 100 E. coli promoters. Acting as a negative regulator against its own synthesis, crp regulates transcription of several catabolite-sensitive operons. Crp activates transcription by making multiple interactions with RNA polymerase. Containing one cyclic nucleotide binding domain and one HTH crp-type DNA binding domain, crp binds DNA as a dimer to induce a severe bend in the DNA. This formation is a regulatory mechanism of crp gene expression that plays a major role in determining the molecular mechanism in gene transcription.

Function:
A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth (PubMed:16260780). Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed:22573269).

Subunit:
Homodimer, which upon binding cAMP is able to bind DNA. AR1 of the upstream subunit binds to the C-terminus of RNAP subunit RpoA, AR2 of the downstream subunit binds to the N-terminus of RpoA while AR3 binds to sigma-70 (RpoD).

Database links:
UniProtKB/Swiss-Prot: P0ACJ8.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Contains 1 cyclic nucleotide-binding domain.
Contains 1 HTH crp-type DNA-binding domain.
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