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Rabbit Anti-INSM2/Gold Conjugated antibody (bs-16676R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-16676R-Gold
英文名稱 Rabbit Anti-INSM2/Gold Conjugated antibody
中文名稱 膠體金標記的胰島素瘤相關蛋白2抗體
別    名 IA 6; IA6; INSM2_HUMAN; Insulinoma associated 2; Insulinoma associated protein 2; mlt1; Zinc finger protein IA 6; Zinc finger protein IA6.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  細胞生物  轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Pig, Cow, Rabbit, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human INSM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
INSM2 is a 566 amino acid nuclear protein. INSM2 is believed to act as a growth or tumor suppressor in certain neurons and in liver cells. INSM2 contains five zinc finger C2H2-type domains which bind nucleic acids. Zinc fingers are composed of 25-30 amino acid residues and have the ability to bind about five nucleotides. C2H2-type zinc fingers have two cysteines on one extremity of the domain, and two histidines on the other extremity. These four cysteines and histidines interact with one zinc atom, resulting in the finger-like conformation of the domain. It is believed that the C2H2-type zinc fingers require the binding of a zinc atom in order for the finger to bind DNA or RNA.

Function:
INSM2 may function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Subcellular Location:
Nuclear

Tissue Specificity:
Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level). {ECO:0000269|PubMed:21343251}.

Similarity:
Contains 5 C2H2-type zinc fingers.

Database links:

Entrez Gene: 84684 Human

Entrez Gene: 56856 Mouse

Entrez Gene: 314131 Rat

SwissProt: Q96T92 Human

SwissProt: Q9JMC2 Mouse

Unigene: 62813 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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