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Rabbit Anti-Influenza A PB1/PE-Cy5.5 Conjugated antibody (bs-16648R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16648R-PE-Cy5.5
英文名稱 Rabbit Anti-Influenza A PB1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的A型流感病毒PB1抗體
別    名 PB1; PB1-F2 protein; PB1F2_I07A0; Protein PB1-F2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 6.6kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Influenza A Influenza A PB1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
產品介紹 Function:
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis (By similarity).

Subunit:
Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 (By similarity).

Subcellular Location:
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol (By similarity).

Similarity:
Belongs to the influenza viruses PB1-F2 family.

Database links:

Entrez Gene: 3802042 Influenza A

SwissProt: P0C0U1 Influenza A



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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