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Rabbit Anti-IPP/AP Conjugated antibody (bs-16686R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16686R-AP
英文名稱 Rabbit Anti-IPP/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的肌動蛋白結合蛋白IPP抗體
別    名 Actin binding protein IPP; Intracisternal A particle promoted polypeptide; IPP POZ; IPP_HUMAN; Kelch like protein 27; KLHL27; MIPP protein;  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  結合蛋白  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IPP
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Function:
Intracisternal A particle promoted polypeptide (IPP) is a member of the kelch family of proteins, characterized by a 50 amino acid repeat which interacts with actin. The kelch domain of IPP consists of six C terminal tandem arranged repeats. IPP may play a role in organizing the actin cytoskeleton. IPP also contains an N terminal POZ protein protein interaction domain. The POZ domain (also called BTB domain) is present near the N terminus of a fraction of zinc finger proteins and in proteins that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co repressor complexes including N-coR and SMRT.

Subcellular Location:
Cytoplasm, cytoskeleton.

Similarity:
Contains 1 BTB (POZ) domain. {ECO:0000255|PROSITE-ProRule:PRU00037}.
Contains 6 Kelch repeats. {ECO:0000305}.

Database links:

Entrez Gene: 3652 Human

Entrez Gene: 785293 Cow

Entrez Gene: 16351 Mouse

Entrez Gene: 298439 Rat

Omim: 147485 Human

SwissProt: Q9Y573 Human

SwissProt: P28575 Mouse

Unigene: 699548 Human

Unigene: 229516 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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