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Rabbit Anti-HHV8 ORF8/Gold Conjugated antibody (bs-16860R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-16860R-Gold
英文名稱 Rabbit Anti-HHV8 ORF8/Gold Conjugated antibody
中文名稱 膠體金標記的人類皰疹病毒8抗體
別    名 Human herpes virus 8 Glycoprotein B-like; HHV 8; Human herpes virus 8; Human herpesvirus 8; Kaposi's sarcoma herpes virus; Kaposi's sarcoma herpes virus; KSHV; ORF8; GB_HHV8P.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 92kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from HHV8/ORF8
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV ORF8 is a virion envelope-associated protein. Akula et al (2003) report it acts as a Glycoprotein B mediated signaling during virus entry. This Glycoprotein possesses the Arg-Gly-Asp (RGD) motif and utilizes alpha3beta1 integrin as one of the receptors for its entry into the target cells.

Function:
Envelope glycoprotein that forms spikes at the surface of the virion envelope. Participates in viral entry through an RGD motif that binds ITGAV-ITGB3. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.

Subunit:
Homotrimer; disulfide-linked (By similarity)

Subcellular Location:
Virion membrane

Similarity:
Belongs to the herpesviridae glycoprotein B family

Database links:
Entrez Gene: 4961501 HHV8 ORF8

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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