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Rabbit Anti-KCNH5/RBITC Conjugated antibody (bs-16886R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16886R-RBITC
英文名稱 Rabbit Anti-KCNH5/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的KCNH5蛋白抗體
別    名 EAG2; Ether a go go potassium channel 2; H EAG2; HGNC:6254; Kv10.2; potassium voltage gated channel subfamily H (eag-related) member 5; Voltage gated potassium channel subunit Kv10.2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  通道蛋白  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 112kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KCNH5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The KCNH5 gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH5 is not expressed in differentiating myoblasts.

Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable).

Subcellular Location:
Cell Membrane: multi-pass membrane protein.

Tissue Specificity:
Detected in brain, skeletal muscle, heart,placenta, lung and liver, and at low levels in kidney.

Similarity:
Belongs to the potassium channel family. Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
Contains 1 cyclic nucleotide-binding domain.
] Contains 1 PAS (PER-ARNT-SIM) domain.


Database links:

Entrez Gene: 27133 Human

Entrez Gene: 238271 Mouse

Entrez Gene: 171146 Rat

Omim: 605716 Human

SwissProt: Q8NCM2 Human

SwissProt: Q6NZH0 Mouse

SwissProt: Q920E3 Mouse

SwissProt: Q9EPI9 Rat

Unigene: 27043 Human

Unigene: 48753 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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