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Rabbit Anti-GPCR MRGE/GPCR GPR167/AP Conjugated antibody (bs-16269R-AP)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-16269R-AP
英文名稱 Rabbit Anti-GPCR MRGE/GPCR GPR167/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的G蛋白偶聯受體167抗體
別    名 G protein coupled receptor 167; G-protein coupled receptor 167; GPR167; Mas related G protein coupled MRGE; MAS related GPR member E; Mas-related G-protein coupled receptor member E; MRGE; MRGPRE; MRGRE_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 信號轉導  細胞凋亡  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPCR MRGE/GPCR GPR167
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MRGE is a 311 amino acid multi-pass membrane protein that acts as an orphan receptor and is though to influence nociceptor function. A member of the G-protein coupled receptor 1 family and MAS subfamily, MRGE is encoded by a gene that maps to human chromosome 11p15.4 and mouse chromosome 7 F5. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular Location:
Cell membrane.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Database links:

Entrez Gene: 116534 Human

Entrez Gene: 244238 Mouse

Entrez Gene: 404660 Rat

Omim: 607232 Human

SwissProt: Q86SM8 Human

SwissProt: Q91ZB7 Mouse

SwissProt: Q7TN40 Rat

Unigene: 706565 Human

Unigene: 183561 Mouse

Unigene: 189891 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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