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Rabbit Anti-TPCN1/AP Conjugated antibody (bs-17163R-AP)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-17163R-AP
英文名稱 Rabbit Anti-TPCN1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的電壓依賴性鈣通道蛋白抗體
別    名 FLJ20612; KIAA1169; TPC1; TPC1_HUMAN; TPCN 1; TPCN1; Two pore calcium channel protein 1; Two pore channel 1; Two pore segment channel 1; Voltage dependent calcium channel protein TPC1; Voltage-dependent calcium channel protein TPC1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPCN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]

Function:
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane.

Subcellular Location:
Lysosome membrane. Endosome membrane.

Tissue Specificity:
Highest expression found in the heart and kidney, and lowest expression found in the spleen.

Similarity:
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.

Database links:

Entrez Gene: 53373 Human

Entrez Gene: 252972 Mouse

Entrez Gene: 246215 Rat

Entrez Gene: 567534 Zebrafish

Omim: 609666 Human

SwissProt: Q9ULQ1 Human

SwissProt: Q9EQJ0 Mouse

SwissProt: Q9WTN5 Rat

Unigene: 524763 Human

Unigene: 114054 Mouse

Unigene: 24484 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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