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Rabbit Anti-IZUMO1/PE-Cy5.5 Conjugated antibody (bs-17192R-PE-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-17192R-PE-Cy5.5
英文名稱 Rabbit Anti-IZUMO1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的IZUMO1蛋白抗體
別    名 IZUM1_HUMAN; IZUMO; Izumo sperm egg fusion 1; Izumo sperm-egg fusion protein 1; Izumo1; MGC34799; OBF; Oocyte binding/fusion factor; Sperm specific protein izumo; Sperm-specific protein izumo.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  發育生物學  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IZUMO1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

Function:
Involved in the fertilization process. May be involved in the fusion of the sperm with the egg.

Subunit:
Monomer, homodimer and homooligomer. Interacts with IZUMO1R/JUNO (By similarity).

Subcellular Location:
Membrane.

Tissue Specificity:
Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.

Post-translational modifications:
N-glycosylated. Glycosylation is not essential for fusion and for proper protein trafficking in sperm.
Phosphorylated.

Similarity:
Belongs to the Izumo family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Database links:

Entrez Gene: 284359 Human

Entrez Gene: 73456 Mouse

Entrez Gene: 499152 Rat

Omim: 609278 Human

SwissProt: Q8IYV9 Human

SwissProt: Q9D9J7 Mouse

SwissProt: Q6AY06 Rat

Unigene: 400688 Human

Unigene: 380445 Mouse

Unigene: 125416 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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