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Rabbit Anti-Alpha neoendorphin/AP Conjugated antibody (bs-10740R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-10740R-AP
英文名稱 Rabbit Anti-Alpha neoendorphin/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的α -新內啡肽抗體
別    名 prodynorphin; proenkephalin-B; Alpha neoendorphin; Alpha-neoendorphin; PDYN_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  神經生物學  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 1kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Alpha neoendorphin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010].

Function:
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.

Subcellular Location:
Secreted.

Post-translational modifications:
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

DISEASE:
Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.

Similarity:
Belongs to the opioid neuropeptide precursor family.

Database links:

Entrez Gene: 5173 Human

Entrez Gene: 18610 Mouse

Entrez Gene: 29190 Rat

Omim: 131340 Human

SwissProt: Q95104 Cow

SwissProt: P01213 Human

SwissProt: O35417 Mouse

SwissProt: P06300 Rat

Unigene: 22584 Human

Unigene: 44471 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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