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Rabbit Anti-KIR2.3/Gold Conjugated antibody (bs-17069R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-17069R-Gold
英文名稱 Rabbit Anti-KIR2.3/Gold Conjugated antibody
中文名稱 膠體金標記的鉀離子通道KIR2.3抗體
別    名 Hippocampal inward rectifier; Hippocampal inward rectifier potassium channel; HIR; HIRK2; HRK1; Inward rectifier K(+) channel Kir2.3; Inward rectifier K+ channel Kir2.3; Inward rectifier potassium channel 4; Inward rectifier potassium channel Kir 2.3; inwardly rectifying subfamily J member 4; IRK-3; IRK3; IRK4_HUMAN; KCNJ 4; Kcnj4; Kir2.3; MGC142066; MGC142068; OTTHUMP00000028922; Potassium channel; Potassium channel inwardly rectifying subfamily J member 4; Potassium inwardly rectifying channel J4; Potassium inwardly rectifying channel subfamily J m  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  神經生物學  通道蛋白  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIR2.3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.

Subcellular Location:
Cell membrane. Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization.

Tissue Specificity:
Heart, skeletal muscle, and several different brain regions including the hippocampus.

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.

Database links:

Entrez Gene: 3761 Human

Entrez Gene: 16520 Mouse

Entrez Gene: 116649 Rat

Omim: 600504 Human

SwissProt: P48050 Human

SwissProt: P52189 Mouse

SwissProt: P52190 Rat

Unigene: 32505 Human

Unigene: 140760 Mouse

Unigene: 10197 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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