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Rabbit Anti-MTG1/GTPBP7/HRP Conjugated antibody (bs-17874R-HRP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-17874R-HRP
英文名稱 Rabbit Anti-MTG1/GTPBP7/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的GTP結合蛋白7抗體
別    名 GTP; GTP binding protein; GTP binding protein 7 (putative); GTP binding protein 7; GTP-binding protein 7 (putative); GTP-binding protein 7; GTPBP7; Mitochondrial GTPase 1; mitochondrial GTPase 1 homolog (S. cerevisiae); MTG1; MTG1_HUMAN; OTTHUMP00000020814; OTTHUMP00000046565; RP11 108K14.2; RP11-108K14.2; RP11108K14.2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  轉錄調節因子  轉運蛋白  線粒體  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Cow, )
產品應用 WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MTG1/GTPBP7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MTH1 is a 179 amino acid cytoplasmic protein that is a member of the nudix hydrolase family. Highly expressed in testis, thymus and proliferating blood lymphocytes, MTH1 functions as an antimutagenic that hydrolyzes oxidized purine nucleoside triphosphates to their corresponding monophosphates. Through its ability to enzymatically hydrolyze ATP and GTP to AMP and GMP, respectively, MTH1 prevents misincorporation of GTP into DNA, thus preventing A:T to C:G transversions. The cytoplasmic location of MTH1, along with its antimutagenic capabilities, suggests that it may also be involved in the sanitization of nucleotide pools for both mitochondrial and nuclear genomes. Four isoforms of MTH1 exist—three of which are formed due to alternative splicing events and one of which is formed via a single-nucleotide polymorphism. Overexpression of MTH1 is implicated in prostate and cell lung carcinomas

Function:
Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit.

Subcellular Location:
Mitochondrion.

Similarity:
Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamily.
Contains 1 G (guanine nucleotide-binding) domain.

Database links:

Entrez Gene: 92170 Human

Entrez Gene: 509768 Cow

Entrez Gene: 212508 Mouse

SwissProt: Q4PS77 Cow

SwissProt: Q9BT17 Human

SwissProt: Q8R2R6 Mouse

Unigene: 501578 Human

Unigene: 296088 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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