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Rabbit Anti-MMS22L/C6orf167/Gold Conjugated antibody (bs-17689R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-17689R-Gold
英文名稱 Rabbit Anti-MMS22L/C6orf167/Gold Conjugated antibody
中文名稱 膠體金標記的6號染色體開放閱讀框抗體
別    名 C6orf167; C6orf167 chromosome 6 open reading frame 167; chromosome 6 open reading frame 167; dJ39B17.2; DKFZp686C20164; DKFZp781C2113; FLJ46180; homologous to yeast Mms22; KIAA1900; Methyl methanesulfonate-sensitivity protein 22-like; MMS22 like, DNA repair protein; Mms22-like protein; MMS22_HUMAN; MMS22L; OTTHUMP00000221009; Protein MMS22-like; Uncharacterized protein C6orf167.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  細胞生物  神經生物學  糖尿病  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 142kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMS22L/C6orf167
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf167 gene product has been provisionally designated C6orf167 pending further characterization.

Function:
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.

Subcellular Location:
Nucleus. Localizes to DNA damage sites, accumulates at stressed replication forks.

Similarity:
Belongs to the MMS22 family. MMS22L subfamily.

Database links:

Entrez Gene: 253714 Human

Entrez Gene: 212377 Mouse

SwissProt: Q6ZRQ5 Human

SwissProt: B1AUR6 Mouse

Unigene: 444292 Human

Unigene: 120919 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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