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Rabbit Anti-LPHN2/Cy3 Conjugated antibody (bs-18349R-Cy3)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-18349R-Cy3
英文名稱 Rabbit Anti-LPHN2/Cy3 Conjugated antibody
中文名稱 Cy3標記的蛛毒素受體2抗體
別    名 Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; CL2; KIAA0786; Latrophilin 1; Latrophilin 2; Latrophilin homolog 1; latrophilin homolog 2; LEC1; Lectomedin-1; LPH2; LPHH1; LPHN2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 160kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LPHN2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. [provided by RefSeq, Jul 2008]

Function:
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.

Subunit:
Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85)

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.

Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.

Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.

Database links:

Entrez Gene: 281278 Cow

Entrez Gene: 100052932 Horse

Entrez Gene: 23266 Human

Entrez Gene: 100405265 Marmoset (common)

Entrez Gene: 99633 Mouse

Entrez Gene: 100013683 Opossum

Entrez Gene: 100524685 Pig

Entrez Gene: 100343149 Rabbit

Entrez Gene: 171447 Rat

Entrez Gene: 100551470 Turkey

Omim: 607018 Human

SwissProt: O97817 Cow

SwissProt: O95490 Human

SwissProt: Q8JZZ7 Mouse

SwissProt: O88923 Rat

Unigene: 24212 Human

Unigene: 9776 Mouse

Unigene: 12089 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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