| 產品編號 | bs-18162R-Gold |
| 英文名稱 | Rabbit Anti-TNS4/Gold Conjugated antibody |
| 中文名稱 | 膠體金標記的張力蛋白4抗體 |
| 別 名 | C terminal tensin like; C terminal tensin like protein; C-terminal tensin-like protein; CTEN; FLJ14950; PP14434; TENS4_HUMAN; Tensin 4; Tensin-4; Tns4. |
| 規格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul（10nm 15nm 35nm） |
| 研究領域 | 腫瘤 細胞生物 信號轉導 細胞粘附分子 細胞骨架 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產品應用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TNS4 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產品介紹 |
background: The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring Actin filaments at the focal adhesion via F-Actin binding and capping activities. Tns proteins contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting an additional role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns4 is a 715 amino acid protein that localizes to focal adhesions and contains one SH2 domain and one phosphatase tensin-type domain. Expressed in placenta and prostate, Tns4 binds to Actin filaments and is thought to be involved in cartilage development, cell migration and apoptosis, and may also play a role in linking signal transduction pathways to the cytoskeleton. Tns4 is subject to post-translational phosphorylation and is down-regulated in prostate cancer cells, suggesting a role in tumor suppression Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3. Subcellular Location: Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Tissue Specificity: Prostate and placenta. Down regulated in prostate cancer. Post-translational modifications: Proteolytically cleaved by caspase-3 during apoptosis. Similarity: Contains 1 phosphatase tensin-type domain. Contains 1 SH2 domain. Database links: Entrez Gene: 84951 Human Entrez Gene: 217169 Mouse Omim: 608385 Human SwissProt: Q8IZW8 Human SwissProt: Q8BZ33 Mouse Unigene: 438292 Human Unigene: 262067 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
